Garcinolic acid | Alomone Labs G-155 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Garcinolic acid

catalog :

G-155

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of human Colo-205 colon adenocarcinoma cell lysate: - 1.Anti-Na+/H+Exchanger 3 (NHE-3) Antibody (#ANX-033) (1:200).2. Anti-Na+/H+Exchanger 3 (NHE-3) Antibody preincubated with the negative control antigen.

product information

CAT :

G-155

SKU :

G-155_0.1 mg

Product Name :

Garcinolic acid

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Garcinolic acid, a type of xanthone, is a positive modulator of the purinergic P2X7 receptors. It facilitates and potentiates cellular responses mediated by the purinergic P2X7 receptors at concentrations over 10 µM1,2.P2X receptors are ligand-gated cation-permeable channel complexes that are activated by extracellular ATP. This family contains seven subtypes: P2X1-P2X7 that can be assembled as trimeric complexes. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are expressed in almost all tissues, particularly in cells of haematopoietic origin1,3.

Supplier :

Alomone Labs

Target :

P2X7 receptors

Long Description :

Garcinolic acid (#G-155) is a highly pure, natural, and biologically active compound.

Short Description :

A Positive Modulator of P2X7 Receptors

MW :

646.78

Synonyms :

CHEMBL1456870

Source :

Natural

Molecular formula :

C38H46O9.

Effective Concentration :

10-100 µM.

Activity :

Garcinolic acid is a natural compound isolated from Garcinia resin, shown to facilitate and potentiate cellular responses mediated by the purinergic P2X7 receptors at over 10 µM1.

Reconstitution and Solubility :

Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CID :

6857794

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(4R)-4-[(2E)-3-carboxy-3-methylprop-2-en-1-yl]-14-hydroxy-6,6,18-trimethyl-21-(3-methylbut-2-en-1-yl)-18-(4-methylpent-3-en-1-yl)-12-oxo-2,5,19-trioxapentacyclo[11.8.0.0^{3,7}.0^{3,11}.0^{15,20}]henicosa-1(21),10,13,15(20),16-pentaene-4-carboxylic acid

more info or order :

Alomone Labs product webpage