product summary
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company name :
Alomone Labs
product type :
chemical
product name :
GV-58
catalog :
G-140
more info or order :
citations: 3
| Reference |
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image
image 1 :
Alomone Labs GV-58 increases P/Q-type CaVchannel tail currents expressed inXenopusoocytes. - A. Time course of CaV2.1 (co-expressed with ?2?1 and ?1 auxiliary subunits) normalized tail current area (see tails in panel B at the end of the ramp stimulation back at -100 mV) elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV (see panel B top) delivered every 10 seconds. Application of 20 and 100 MGV-58(#G-140) increases the CaV2.1 tail current (periods of application are indicated by the horizontal bars) up to 18 fold in a reversible manner. B. Representative current traces before and during application of 20 and 100 M GV-58 as indicated. Note the lack of effect on CaVcurrents during the ramp stimulation.
image 2 :
Peptide (C)EKQHEVYWKVSEDK corresponding to amino acid residues 80-93 of mouse SEMA4D (Accession O09126). Extracellular N-terminus.
product information
CAT :
G-140
SKU :
G-140_10 mg
Product Name :
GV-58
Group Type :
Non Antibodies
Product Type :
S. Molecules
Storage After Reconstitution :
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Product Page - Scientific background :
GV-58, a Ca2+ channel agonist, is selective for N- (CaV2.2) and P/Q-type (CaV2.1) channels. GV-58 was developed as a modification of (R)-roscovitine, which was previously shown to be a Ca2+ channel agonist. 100 μM GV-58 was originally tested on N-, P/Q-, or L-type channels expressed in tsA-201 cells. GV-58 was shown to be more potent on N- and P/Q Ca2+ channels with an EC50 = 6.8 and 9.9 μM, respectively over L-type calcium channels (EC50 > 100 μM)1. GV-58 slows the closing of the channel, resulting in a large increase in total Ca2+ entry during motor nerve action potential activity.GV-58 is being tested for the treatment of neuromuscular weakness2.
Supplier :
Alomone Labs
Target :
CaV2.1, CaV2.2 Ca2+ channels
Long Description :
GV-58 (#G-140) is a highly pure, synthetic, and biologically active compound.
Short Description :
An Activator of CaV2.2 and CaV2.1 Ca2+ Channels
MW :
374.2
Source :
Synthetic
Molecular formula :
C18H26N6OS.
Effective Concentration :
1-100 µM.
Activity :
GV-58 is an opener of N- and P/Q-type Ca2+ channels1.
Reconstitution and Solubility :
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Solubility :
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage of solutions :
Up to four weeks at 4°C or three months at -20°C.
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Purity :
>98%
CAS No :
1402821-41-3
Form :
Lyophilized powder.
Comment :
Contact Alomone Labs for technical support and product customization
UNSPSC :
41116134
Bioassay Tested :
Yes
Chemical Name :
(2R)-2-[(6-{[(5-Methylthiophen-2-yl)methyl]amino}-9-propyl-9H-purin-2-yl)amino]butan-1-ol.
more info or order :
company information
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972 2 531 8002
headquarters: Israel
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