GMQ | Alomone Labs G-130 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

GMQ

catalog :

G-130

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs GMQmodulates ASIC3 channels expressed inXenopusoocytes. - A. Time course of ASIC3 currents that were elicited by stimulation with pH 5.5 every 100 sec while membrane potential was held at -60 mV. 1 mMGMQ(#G-130) was applied for 4 min as indicated caused reversible complex effect combining peak amplitude depression with diminished inactivation as seen with superimposed traces in B.

product information

CAT :

G-130

SKU :

G-130_10 mg

Product Name :

GMQ

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied1,2.GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition, GMQ contains a guanidinium group and a heterocyclic ring.Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner3.

Supplier :

Alomone Labs

Target :

ASIC1a, ASIC2, ASIC3

Long Description :

GMQ (#G-130) is a highly pure, synthetic, and biologically active compound.

Short Description :

An ASIC Channel Modulator and an ASIC3 Channel Opener

MW :

201.2

Synonyms :

2-GMQ, 2-Guanidine-4-methylquinazoline

Source :

Synthetic

Molecular formula :

C10H11N5.

Effective Concentration :

1-5 mM.

Activity :

GMQ is an ASIC modulator, ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

0.99

CAS No :

716-11-0

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-(4-methylquinazolin-2-yl)guanidine.

more info or order :

Alomone Labs product webpage