GYKI 52466 hydrochloride | Alomone Labs G-125 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

GYKI 52466 hydrochloride

catalog :

G-125

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs GYKI 52466 hydrochloride blocks GluA1 receptors expressed inXenopusoocytes. - A. Time course of 300 ?MGYKI 52466 hydrochloride(#G-125) reversible inhibitory action on glutamate-elicited currents (100 ?M delivered every 100 seconds holding potential -60 mV). B. Superimposed current traces of control and inhibited current as indicated (taken from the experiment in A).

image 2 :

Peptide (C)HEHVDRYVPHREHNHRE corresponding to amino acid residues 571-587 of rat CACNB2 (AccessionQ8VGC3). Intracellular C-terminus.

product information

CAT :

G-125

SKU :

G-125_10 mg

Product Name :

GYKI 52466 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

GYKI 52466 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. It blocks GluK3 homomeric receptors with an IC50 of 63 μM and GluK2b(R)/GluK3 heteroreceptors with an IC50 of 32 μM at high concentrations. GYKI 52466 has been reported to prevent the excitotoxic action of high extracellular glutamate levels due to its potent non-competitive AMPA receptor antagonistic effect. It has been demonstrated histologically that GYKI 52466 has neuroprotective actions in experimental models of global and focal cerebral ischaemia. The compound was widely investigated in experimental seizure models, where it provided effective protection against convulsions evoked by chemical agents such as AMPA or kainate, electroshock and audiogenic stimulation1.

Supplier :

Alomone Labs

Target :

AMPA/Kainate receptors

Long Description :

GYKI 52466 hydrochloride (#G-125) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of AMPA and Kainate Receptors

MW :

329.78

Source :

Synthetic

Molecular formula :

C17H16ClN3O2.

Effective Concentration :

300 nM - 300 µM.

Activity :

GYKI 52466 is a selective allosteric AMPA/kainate receptor antagonist, with an IC50 of ~10 μM for AMPA induced currents in cultured superior colliculus neurons1.

Reconstitution and Solubility :

30 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Solubility :

30 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96.6%

CAS No :

192065-56-8

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride.

more info or order :

Alomone Labs product webpage