chemical

Ganaxolone

G-120

G-120_10 mg

Ganaxolone

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Ganaxolone (CCD 1042) is a 3β-methyl-substituted synthetic analogue of the endogenous neuroactive steroid allopregnanolone with anticonvulsant, anxiolytic, and sedative effects. The methyl group on the compound makes it more resistant to metabolism and increases the compound's half life by hours.Ganaxolone is a selective, potent and positive allosteric modulator of the GABA(A) receptors. It enhances the binding of the benzodiazepine and the GABA sites. In several clinical studies, ganaxolone treatment showed to have protective activity in several seizures models in adults and in children with history of infantile spasms. In adults the compound successfully reduced the frequency of partial seizures2,3.Ionotropic GABA(A) receptors mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. The receptors are considered to be a major target of antiseizure drugs1,2.

Alomone Labs

GABA(A) receptors

Ganaxolone (#G-120) is a highly pure, synthetic, and biologically active compound.

A Selective Positive Modulator of GABA(A) Receptors

332.5

CCD-1042, 3α-Hydroxy-3β-methyl-5α-pregnan-20-one, AC1OCF9O, UNII-98WI44OHIQ

Synthetic

C22H36O2.

0.01-10 μM.

Ganaxolone potentiates GABA-evoked chloride currents. In Xenopus oocytes expressing the human GABA(A) receptor subunits α2β1γ2L, α3β1γ2L and α1β1γ2L the respective EC50 values are 94, 122 and 213 nM1. It is also used as an anticonvulsant, antiepileptic drug2.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

≥99%

38398-32-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone.