chemical

GW 791343 hydrochloride

G-115

G-115_10 mg

GW 791343 hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

GW 791343 hydrochloride is a species-specific allosteric modulator of purinergic P2X7 receptor. The compound acts as a negative modulator of human P2X7 receptors and as a positive modulator of rat P2X71. GW 791343 displays pIC50 values between 6.9 - 7.2 on human P2X7 receptors1,2.P2X receptors are a family of ligand-gated cation channels activated by extracellular ATP, a ligand that mediates numerous cellular and biological functions. Seven members of P2X receptors are identified and shown to function either in homomeric or heteromeric combinations. The P2X receptors are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune and play a pivotal role in models of various pain conditions. P2X7 receptors are responsible for mediating the release of proinflammatory cytokines in inflammatory/immune conditions and pain1,3,4.

Alomone Labs

P2X7 receptors

GW 791343 hydrochloride (#G-115) is a highly pure, synthetic, and biologically active compound.

A Negative Allosteric Modulator of Human P2X7 Receptors

483.81

GW 791343 trihydrochloride, 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride

Synthetic

C20H27Cl3F2N4O ( C20H24F2N4O · 3HCl ).

0.1-10 µM.

GW 791343 hydrochloride is a species-specific allosteric modulator of the purinergic P2X7 receptors, acting as a negative modulator of human P2X7 (pIC50 = 6.9 - 7.2), and as a positive modulator of rat P2X71,2.

Soluble up to 100 mM in DMSO and in water. Centrifuge all products before handling (10000 x g 5 min).

Soluble up to 100 mM in DMSO and in water. Centrifuge all products before handling (10000 x g 5 min).

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

309712-55-8

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

2-(3,4-difluoroanilino)-N-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]acetamide trihydrochloride.