chemical

FPTQ

F-185

F-185_10 mg

FPTQ

Non Antibodies

S. Molecules

https://www.uniprot.org/uniprotkb/P0C1Z0/entry

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

FPTQ is a synthetic compound that acts as a potent and selective allosteric antagonist of mGluR1 receptors. The compound shows very little inhibition of mGluR5 receptors. FPTQ shows high specific binding with mGluR1 receptor in the rat brain and displays IC50 values of 3.6 nM for human mGluR1 expressed in CHO cells1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) and play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found in somatodendritic domains and postsynaptically regulate neuronal excitability and synaptic transmission through several intracellular second messenger systems3,4.

Alomone Labs

mGluR1

FPTQ (#F-185) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of mGluR1 Receptors

305.3

Synthetic

C17H12FN5.

10 nM - 10 µM.

FPTQ is a selective allosteric antagonist of the mGluR1 receptors, inhibiting [3H]FTIDC binding with Ki of 14 nM, and inhibiting L-glutamate evoked Ca2+ mobilization with IC50 of 3.6 nM in CHO cells expressing human mGluR11. It specifically binds mGluR1 in the rat brain2.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

Up to 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

-20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>97%

864863-72-9

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinolone.