Frescolat MGA | Alomone Labs F-165 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Frescolat MGA

catalog :

F-165

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4)brain membranes: - 12.Anti-LRRK2 Antibody (#ANR-102) (1:200).34. Anti-LRRK2 Antibody preincubated with the negative control antigen.

product information

CAT :

F-165

SKU :

F-165_1 g

Product Name :

Frescolat MGA

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca2+ levels with an EC50 value of 4.8 µM1.TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies1,2.

Supplier :

Alomone Labs

Target :

TRPM8 channel

Long Description :

Frescolat MGA (#F-165) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Activator of TRPM8 Channels

MW :

228.33

Synonyms :

Menthone 1,2-glycerol ketal

Source :

Synthetic

Molecular formula :

C13H24O3.

Effective Concentration :

0.1-10 µM.

Activity :

Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.

Reconstitution and Solubility :

Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

63187-91-7

Form :

Colorless Liquid

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol.

more info or order :

Alomone Labs product webpage