FPL 64176 | Alomone Labs F-160 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

FPL 64176

catalog :

F-160

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide CKALHVLFERVSEE corresponding to amino acid residues 183-196 of mouse LRRK2 (AccessionQ5S006). N-terminus.

product information

CAT :

F-160

SKU :

F-160_10 mg

Product Name :

FPL 64176

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

FPL 64176 acts as a non-dihydropyridine L-type calcium channel activator with high efficacy properties. It's a benzoylpyrrole compound that has the ability to increase macroscopic inward current through L-type calcium channels. It extends the opening of single calcium channels during depolarization and slows channel closing upon repolarization without affecting currents through other calcium channels1-3.FPL 64176 is being used as a tool for studying the physiological roles and disorders of L-type channels, identification of L-type currents within the mix of channel subtypes and for increasing the contractility of smooth and cardiac muscle2.The use of FPL 64176 has revealed an inactivation and adaptation process for ryanodine receptors and the presence of cardiac sparklets3,4.L-type voltage-gated calcium channels are one of the three major classes (CaV1-CaV3) of voltage-gated calcium channels. They are expressed in many excitable tissues and play as important transducers in the plasma membrane, altering membrane depolarization to intracellular signaling. Many physiological functions, including brain, endocrine, and sensory functions and muscle contraction rely on proper L-type channel activity5.

Supplier :

Alomone Labs

Target :

L-type Ca2+ channels

Long Description :

FPL 64176 (#F-160) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Opener of L-type Ca2+ Channels

MW :

347.4

Source :

Synthetic

Molecular formula :

C22H21NO3.

Effective Concentration :

10 nM - 1 µM.

Activity :

FPL 64176 is an L-type Ca2+ channel activator, which induces contraction in rat tail artery1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10 000 x g for 1 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10 000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99% (HPLC)

CAS No :

120934-96-5

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate.

more info or order :

Alomone Labs product webpage