DL-AP3 | Alomone Labs D-275 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

DL-AP3

catalog :

D-275

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide (C)HVRSYSPDWPHQPNK corresponding to amino acid residues 507-521 of mouse LINGO-1 (AccessionQ9D1T0). Extracellular N-terminus.

image 2 :

product information

CAT :

D-275

SKU :

D-275_100 mg

Product Name :

DL-AP3

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

DL-AP3 is a racemic compound of 2-amino-3-phosphonopropionic acid that acts as a potent and competitive antagonist of mGluR1 receptors. It demonstrates an IC50 value of 1 mM for rat mGluR1 when challenged with glutamate2. DL-AP3 has neuroprotective effects in the gerbil model of global ischemia1,2.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating, in part, metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8. Type 1 mGluRs are mainly detected on post-synaptic neurons and affect the fate of neuronal progenitor cells and neural stem cells, and are important for the formation of the hippocampus3.

Supplier :

Alomone Labs

Target :

mGluR1

Long Description :

DL-AP3 (#D-275) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of mGluR1 Receptors

MW :

169.07

Synonyms :

DL-2-Amino-3-phosphonopropionic acid

Source :

Synthetic

Molecular formula :

C3H8NO5P.

Effective Concentration :

0.1-10 mM.

Activity :

DL-AP3 is a selective competitive antagonist of group I metabotropic glutamate receptors, at 1 mM suppressing mGluR1 response in an agonist dependent manner1.

Reconstitution and Solubility :

Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

5652-28-8

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-amino-3-phosphonopropanoic acid.

more info or order :

Alomone Labs product webpage