DM-PPP | Alomone Labs D-255 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

DM-PPP

catalog :

D-255

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse muscle myoblast (C2C12) human brain glioblastoma (U-87 MG) human colorectal adenocarcinoma (HT-29) cell lines: - 1-3. Anti-UCP2 Antibody(#ANT-128) (1:200).4-6. Anti-UCP2 Antibody preincubated with the negative control antigen.

product information

CAT :

D-255

SKU :

D-255_10 mg

Product Name :

DM-PPP

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Storage before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

DM-PPP is a synthetic compound that acts as a selective and non-competitive antagonist of mGluR1 receptors with an IC50 value of 15.8 nM1. The compound interacts with the 7 transmembrane (7TM) domain of the receptor. In several animal models DM-PPP shows antinociceptive properties1.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly expressed on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells and neural stem cell and the formation of the hippocampus2.

Supplier :

Alomone Labs

Target :

mGluR1

Long Description :

DM-PPP (#D-255) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Antagonist of mGluR1 Receptors

MW :

309.19

Synonyms :

CHEMBL232052, GTPL1383, BDBM50204428

Source :

Synthetic

Molecular formula :

C17H27NO4.

Effective Concentration :

1 nM - 1 µM.

Activity :

DM-PPP is a selective and non-competitive antagonist of mGluR1 receptors. It inhibits the receptor in CHO cells with an IC50 of 15.8 nM1.

Reconstitution and Solubility :

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CID :

44431042

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4-O-[(2S)-3,3-dimethylbutan-2-yl] 2-O-propyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate.

more info or order :

Alomone Labs product webpage