chemical

DQP-1105

D-210

D-210_10 mg

DQP-1105

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

DQP-1105 is a potent and noncompetitive antagonist of GluN2D and GluN2C-containing N-methyl-d-aspartate (NMDA) receptors displaying IC50 values of 2.7 µM and 8.5 µM towards NR2D and NR2C-containing receptors, respectively1. DQP-1105 exhibits significant selectivity towards these receptors over NR2B and NR2A-containing receptors. DQP-105 inhibits the pregating step without changing the stability of the open pore conformation.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation, glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.

Alomone Labs

GluN2D and GluN2C-containing NMDA receptors

DQP-1105 (#D-210) is a highly pure, synthetic, and biologically active compound.

A Potent Noncompetitive Antagonist of GluN2D/C-Containing NMDA Receptors

558.43

Synthetic

C29H24BrN3O4.

1-20 µM.

DQP-1105 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 2.7 µM and 8.5 µM, respectively) over NR2B and NR2A-containing receptors (IC50 = 121 µM and 206 µM, respectively)1.

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

380560-89-4

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

4-[(3Z)-5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenylquinolin-3-ylidene)pyrazolidin-1-yl]-4-oxobutanoic acid.