DL-AP7 | Alomone Labs D-200 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

DL-AP7

catalog :

D-200

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs PD-161989 2-hydroxyethanesulfonate inhibits GluA1 channels expressed inXenopusoocytes. - Time course of GluA1 current activation by application (top dotted line) of 1 M glutamate and its reversibe inhibition by 2 M and 10 MPD-161989 2-hydroxyethanesulfonate(#P-285) as indicated (bars) at a holding potential of -80 mV.

product information

CAT :

D-200

SKU :

D-200_10 mg

Product Name :

DL-AP7

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Storage before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

DL-AP7 (APH) is a competitive N-methyl-D-aspartate (NMDA) receptor antagonist. The mechanism of action of DL-AP7 is to compete with agonists over the recognition site of the NMDA receptor in order to prevent the receptor's activation.Several studies have shown that NMDA receptor blockade evokes changes of systemic pressure; DL-AP7 administration may increase blood pressure. This finding indicates that peripherally, NMDA receptors may take part in regulating the cardiovascular system1,2.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate several physiological functions including learning and memory formation, they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease3.

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

DL-AP7 (#D-200) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of NMDA Receptors

MW :

225.19

Synonyms :

APH

Source :

Synthetic

Molecular formula :

C7H16NO5P.

Effective Concentration :

1-250 µM.

Activity :

DL-AP7 is an NMDA receptor antagonist1.

Reconstitution and Solubility :

100 mM in 1N NaOH solution. Centrifuge all product preparations before use (10,000 x g for 1 min).

Solubility :

100 mM in 1N NaOH solution. Centrifuge all product preparations before use (10,000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

78966-69-5

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-amino-7-phosphonoheptanoic acid.

more info or order :

Alomone Labs product webpage