chemical

5,7-Dichlorokynurenic acid monohydrate

D-191

D-191_10 mg

5,7-Dichlorokynurenic acid monohydrate

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

5,7-Dichlorokynurenic acid (5,7-DCKA), is a derivative of kynurenic acid, an extremely potent excitatory amino acid receptor antagonist of N-methyl-D-aspartate (NMDA) receptors. 5,7-DCKA binds with high affinity to a strychnine-insensitive glycine binding site located on the NMDA receptor. This site is considered to be used as a therapeutic target for acute focal ischemia. The compound exhibits strong selectivity for binding to GluN1 subunit over GluN3A1,2 with an IC50 value of 79 nM in rat cortical and hippocampal membranes4.Small concentrations of 5,7-DCKA have the ability to inhibit several processes including NMDA-stimulated elevation of cytosolic calcium in cultured hippocampal neurons, cGMP accumulation in cerebellar slices, and norepinephrine release from hippocampal regions1.Several different studies have demonstrated potent anticonvulsant features of 5,7-DCKA when the compound is administrated intra-cerebroventricularly directly to the brain1.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. They mediate several physiological functions including learning and memory formation; they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease.

Alomone Labs

NMDA receptors

5,7-Dichlorokynurenic acid monohydrate (#D-191) is a highly pure, synthetic, and biologically active compound.

An Antagonist of NMDA Receptors

276.07

Synthetic

C10H7Cl2NO4.

0.5-20 µM.

5,7-Dichlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site1.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

190908-40-8

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid; hydrate.