product summary
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company name :
Alomone Labs
product type :
chemical
product name :
NaV1.7-Compound 36
catalog :
CMN-003
more info or order :
product information
CAT :
CMN-003
SKU :
CMN-003_10 mg
Product Name :
NaV1.7-Compound 36
Group Type :
Non Antibodies
Product Type :
S. Molecules
Storage After Reconstitution :
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Storage before Reconstitution :
The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Product Page - Scientific background :
NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. NaV1.7-Compound 36 inhibits human NaV1.7 channels with IC50 value of 69 nM1.There are nine mammalian subtypes of NaV channels: NaV1.1-NaV1.9. They are essential for the initiation of action potentials in excitable cells and are considered to be important therapeutic targets for numerous pathophysiological conditions such as cardiac arrhythmia, and epilepsy. NaV1.7 channel plays an important role in nociception and it is an important therapeutic target in chronic pain1,2.
Supplier :
Alomone Labs
Target :
NaV1.7 channels
Long Description :
NaV1.7-Compound 36 (#CMN-003) is a highly pure, synthetic, and biologically active compound.
Short Description :
A Potent and Selective Blocker of NaV1.7 Channels
MW :
486.85
Synonyms :
4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide
Source :
Synthetic
Molecular formula :
C20H14ClF3N2O5S.
Effective Concentration :
50 nM - 50 µM.
Activity :
NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. It inhibits human NaV1.7 with IC50 of 69 nM. Compound 36 is selective for NaV1.7 over other human NaV isoforms and important targets, such as hERG1.
Reconstitution and Solubility :
Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Solubility :
Soluble up to 200 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Storage of solutions :
Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Purity :
>99% (HPLC)
CAS No :
1694633-51-6
Form :
Lyophilized Powder
Comment :
Contact Alomone Labs for technical support and product customization
UNSPSC :
41116134
Bioassay Tested :
Yes
Chemical Name :
4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide.
more info or order :
company information

Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972 2 531 8002
headquarters: Israel
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