CGS 20625 | Alomone Labs C-390 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

CGS 20625

catalog :

C-390

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain membrane (lanes 1 and 4) rat brain membrane (lane 2 and 5) and rat cortex lysate (lane 3 and 6): - 1-3. Anti-CRF1/CRHR1 (extracellular) Antibody(#ACR-050) (1:200).4-6. Anti-CRF1/CRHR1 (extracellular) Antibody preincubated with the negative control antigen.

product information

CAT :

C-390

SKU :

C-390_10 mg

Product Name :

CGS 20625

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Storage before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

CGS 20625 is a synthetic compound that acts as a potent and selective partial agonist of GABA(A) receptors.CGS 20625 is a pyrazolopyridine compound that possesses anxiolytic and anticonvulsant characteristics. It binds to a specific recognition site on GABAA receptors containing α1, α2, α3, and α5 subunits1-3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA actions, a major inhibitory neurotransmitter, throughout the central nervous system where it plays an important role in inhibiting cell excitation. GABA(A) receptors are a major target for antiseizure drugs4.

Supplier :

Alomone Labs

Target :

GABA(A) receptors

Long Description :

CGS 20625 (#C-390) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Partial Agonist of GABA(A) Receptors

MW :

309.36

Source :

Synthetic

Molecular formula :

C18H19N3O2.

Effective Concentration :

1-100 µM.

Activity :

CGS 20625 acts as a partial agonist at GABA(A) receptors (EC50 = 11.2-23.7 µM)1. It is a potent and selective non-benzodiazepine ligand at the central benzodiazepine receptor (IC50 = 1.3 nM), with anxiolytic and anticonvulsant effects in vivo2.

Reconstitution and Solubility :

Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).

Solubility :

Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

111205-55-1

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one.

more info or order :

Alomone Labs product webpage