chemical

Chlormethiazole hydrochloride

C-360

C-360_1 g

Chlormethiazole hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the β-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1,2,3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.

Alomone Labs

GABA(A), Glycine receptors

Chlormethiazole hydrochloride (#C-360) is a highly pure, synthetic, and biologically active compound.

A Positive Modulator of GABA(A) and Glycine Receptors

198.11

Somnevrin hydrochloride

Synthetic

C6H9Cl2NS.

0.01-1 mM.

Chlormethiazole both directly activates GABAA receptors (at 0.3 - 1 mM), and potentiates GABA-induced activation at various GABAA receptor subtypes (with EC50 of 20 - 160 µM)1. It was also shown to potentiate glycine-induced currents in both bovine chromaffin cells and murine spinal neurons (at 100 µM)2.

Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>96%

6001-74-7

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

5-(2-chloroethyl)-4-methyl-1,3-thiazole;hydrochloride.