chemical

Cl-HIBO

C-355

C-355_10 mg

Cl-HIBO

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Cl-HIBO (chloro-homoibotenic acid) acts as a full agonist at AMPA receptors (AMPARs). Cl-HIBO is the most selective agonist reported to-date for GluR1/2. Thus, the compound is considered to be a valuable tool for studying the biological behavior and distribution of AMPARs1.The ionotropic glutamate AMPA receptors are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.

Alomone Labs

AMPA receptors

Cl-HIBO (#C-355) is a highly pure, synthetic, and biologically active compound.

An Agonist of AMPA Receptors

206.58

4-Chlorohomoibotenic acid

Synthetic

C6H7ClN2O4.

0.1-100 µM.

Cl-HIBO is an AMPA receptor agonist, highly selective for GluR1 and GluR2 subunit-containing receptors (EC50 for rat recombinant homomeric GluR1, 2, 3 and 4 receptors are 4.7, 1.7, 2700 and 1300 μM, respectively)1.

Up to 20 mM in H2O (slow). Centrifuge all products before reconstitution (10000 x g 5 min).

Up to 20 mM in H2O (slow). Centrifuge all products before reconstitution (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99% (HPLC)

909400-43-7

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid.