chemical

Clobenpropit dihydrobromide

C-345

C-345_10 mg

Clobenpropit dihydrobromide

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Clobenpropit dihydrobromide (VUF 9153) is a synthetic compound that acts as a potent, selective and competitive antagonist of the histamine H3 receptor and shows partial agonist activity towards the histamine H4 receptor. In addition, the compound acts as an antagonist of N-Methyl-d-aspartate (NMDA) receptors1 and displays IC50 values of 1 µM-14 µM2.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke, and mediate physiological functions such as learning and memory formation and participates in glutamate excitotoxicity2. Histamine H3 receptors are presynaptic G-protein coupled receptors that are expressed in the central nervous system. They regulate the release of several neurotransmitters, including biogenic amines, acetylcholine, GABA and glutamate3.

Alomone Labs

Histamine H3, Histamine H4, NMDA receptors

Clobenpropit dihydrobromide (#C-345) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of Histamine H3 Receptors and an Antagonist of NMDA Receptors

470.65

VUF 9153

Synthetic

C14H19Br2ClN4S.

10 nM - 10 µM.

Clobenpropit dihydrobromide is a potent and selective antagonist/inverse agonist of the histamine H3 receptors (pA2 = 9.93), with partial agonist activity at histamine H4 receptors1. It is also an antagonist of the NMDA receptors (IC50 1 µM - 14 µM)2.

Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).

Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

145231-35-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

3-(1H-imidazol-5-yl)propyl N'-[(4-chlorophenyl)methyl]carbamimidothioate;dihydrobromide.