chemical

Cannabichromene

C-315

C-315_1 mg

Cannabichromene

Non Antibodies

S. Molecules

https://www.uniprot.org/uniprotkb/P00980/entry

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Cannabichromene (CBC) is a member of the cannabinoids, compounds derived from a diterpene structure origin of the marijuana plant Cannabis sativa, and particularly abundant in freshly harvested dry-type Cannabis material. These compounds have been used for over a 1000 years as medicinal agents for the relief of pain, as well as for recreational purposes1.CBC is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1) channels and enzymes of the endocannabinoid system. In addition, it also acts as a TRPM8 antagonist.CBC selectively reduces inflammation-induced hypermotility in vivo independently from cannabinoid receptors or TRPA11,2.Several studies have demonstrated that CBC exerts antimicrobial, anti-inflammatory, analgesic and antidepressant-like activity in rodents and has the ability to normalize in vivo intestinal motility in an experimental model of intestinal inflammation3.Cannabichromene potency tested induced TRPA1-mediated Ca2+ elevation showed efficacy of EC50 of 90 nM1.

Alomone Labs

TRPA1, TRPM8 channels, Cannabinoid receptor 1

Cannabichromene (#C-315) is a highly pure, synthetic, and biologically active compound.

An Activator of TRPA1 Channels and an Antagonist of Cannabinoid Receptor 1 and TRPM8 Channels

314.5

Cannabichrome, Pentylcannabichromene, CBC

Synthetic

C21H30O2.

10 nM - 100 µM.

CBC is an activator of TRPA1 with an EC50 of 90 nM and a blocker of TRPM8 with an IC50 of 40 µM1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

20675-51-8

Oily material.

Contact Alomone Labs for technical support and product customization

41116134

Yes

2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromen-5-ol.