chemical

CGS 19755

C-310

C-310_10 mg

CGS 19755

Non Antibodies

S. Molecules

https://www.uniprot.org/uniprotkb/P05484/entry

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

CGS 19755 (Selfotel) is a highly selective, potent and competitive N-methyl-D-aspartate (NMDA) receptor antagonist. The compound binds directly to the postsynaptic NMDA receptor, competing with glutamate. CGS 19755 is a racemic mixture and a rigid analogue of 2-amino-5-phosphonopenranoic acid (AP5). The compound demonstrates anticonvulsant, anxiolytic and anti-ischemic effects. Clinically, intravenous administration of CGS 19755 is preferential over oral administration as the drug is not very active when administered orally1,2. Several studies have found that CGS 19755 has the ability to limit neuronal damage in animal stroke models.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. They mediate physiological functions such as learning and memory formation. These receptors play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions3. NMDA antagonists are effective in limiting ischemic damage to the brain and spinal cord. As shown in several studies, this compound has the ability to prevent ischaemia-induced hippocampal cell damage in gerbils.These anti-ischemic properties make this compound an attractive application for clinical investigation4,5.

Alomone Labs

NMDA receptors

CGS 19755 (#C-310) is a highly pure, synthetic, and biologically active compound.

An NMDA Receptor Antagonist

223.16

Selfotel

Synthetic

C7H14NO5P.

0.01-10 µM.

CGS 19755 is a potent and competitive NMDA receptor antagonist1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

20 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>95%

110347-85-8

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid.