chemical

CNS-1102

C-305

C-305_10 mg

CNS-1102

Non Antibodies

S. Molecules

https://www.uniprot.org/uniprotkb/P05484/entry

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

CNS-1102 is a potent, non-competitive, and selective NMDA receptor (N-methyl-D-aspartate) antagonist. In animals, CNS-1102 reduces the volume of ischemic cerebral infarction and in humans it is being used as a potential agent for the treatment of acute ischemic stroke or neurotrauma stroke. It has the ability to protect white and gray matter from ischemic injury1,2.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. They also mediate physiological functions such as learning and memory formation, glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease3.

Alomone Labs

NMDA receptors

CNS-1102 (#C-305) is a highly pure, synthetic, and biologically active compound.

A Potent NMDA Receptor Antagonist

339.86

Cerestat, Aptiganel hydrochloride

Synthetic

C20H22ClN3.

1 nM - 1 µM.

CNS-1102 is a potent, use-dependent, non-competitive blocker of NMDA receptors, exhibiting high affinity for the central ion channel site (IC50 = 36 nM versus [3H]-MK-801)1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.

Up to 100 mM in DMSO and to 50 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

137160-11-3

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1-(3-ethylphenyl)-1-methyl-2-naphthalen-1-ylguanidine hydrochloride.