CIQ | Alomone Labs C-275 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

CIQ

catalog :

C-275

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs BeKm-1 inhibits KV11.1 channel current expressed inXenopusoocytes. - A. Representative time course ofKV11.1 channel current inhibition by 10 nM BeKm-1(#STB-470) as indicated (green). Membrane potential was held at -100 mV. Current was elicited every 10 sec by a 200 ms voltage step to 0 mV followed by a 200 ms step to -20 mV. B. Superimposed traces of KV11.1 current after application of control solution (black) and of 10 nM BeKm-1 (green) taken from the recording in A.

image 2 :

product information

CAT :

C-275

SKU :

C-275_10 mg

Product Name :

CIQ

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Product Page - Scientific background :

CIQ is a positive allosteric potentiator selective for NR2C- and NR2D-containing N-methyl-d-aspartate (NMDA) receptors. The compound does not potentiate other NMDA receptor subtypes or AMPA and kainate receptors. The activity of CIQ depends on a single residue in the M1 region of the receptor1,2. CIQ demonstrates potentiating EC50 values of 2.7 and 2.8 μM for NR2C- and NR2D-containing receptors, respectively1.NMDA receptors are tetrameric entities composed of two obligatory GluN1 and two GluN2 subunits. They play important roles in numerous cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. NMDA receptors also mediate physiological functions such as learning and memory formation. They are also involved in many neurodegenerative conditions including Alzheimer's disease2,3.

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

CIQ (#C-275) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Potentiator of GluN2C/GluN2D-Containing NMDA Receptors

MW :

467.95

Synonyms :

(3-Chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone

Source :

Synthetic

Molecular formula :

C26H26ClNO5.

Effective Concentration :

1-20 µM.

Activity :

CIQ is an NR2C and NR2D selective potentiator of NMDA receptors. It enhances receptor responses two-fold with EC50 of 3 µM by increasing channel opening frequency1.

Solubility :

Soluble in DMSO up to 100 mM. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99% (HPLC)

CAS No :

486427-17-2

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

more info or order :

Alomone Labs product webpage