Co 102862 | Alomone Labs C-160 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Co 102862

catalog :

C-160

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Co 102862 inhibits NaV1.7 channel currents in HEK293cells. - A. Time course of current reversible inhibition by 50 MCo 102862(#C-160). Currents were elicited by a voltage ramp from a holding potential of -100 mV to 60 mV (30 ms) delivered every 10 seconds. B. Example traces of current response to voltage ramp stimulation before and during application of 50 M Co 102862.

product information

CAT :

C-160

SKU :

C-160_10 mg

Product Name :

Co 102862

Group Type :

Non Antibodies

Product Type :

S. Molecules

Accession :

https://www.uniprot.org/uniprotkb/P26441/entry

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Storage before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Voltage-gated Na+ channels play key roles in determining neuronal excitability1,2. Voltage- and use-dependent blockage of voltage-gated Na+ channels appear to be important in the mechanism of action of many anticonvulsants (e.g. phenytoin (PHT), carbamazepine (CBZ) and lamotrigine (LTG)), local anesthetics (e.g. lidocaine and bupivacaine) and Class I antiarrhythmics3-10.Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel11. IC50 values are 0.28-15.9 μM in rat hippocampal neurons11.Co 102862 is an anticonvulsant, demonstrating potent activity in rodent models of tonic/clonic and partial-complex seizures12.

Supplier :

Alomone Labs

Target :

NaV Na+ channels

Long Description :

Co 102862 (#C-160) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent, State-Dependent Blocker of Neuronal NaV Channels

MW :

273.3

Synonyms :

V102862

Source :

Synthetic

Molecular formula :

C14H12FN3O2.

Effective Concentration :

0.1-200 μM

Activity :

Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel1. IC50 values are 0.28-15.9 µM in rat hippocampal neurons2. It is an anticonvulsant, demonstrating potent activity in rodent models of tonic/clonic and partial-complex seizures3.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96% (HPLC)

CAS No :

181144-66-1

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide.

more info or order :

Alomone Labs product webpage