chemical

CNQX disodium salt

C-141

C-141_1 mg

CNQX disodium salt

Non Antibodies

S. Molecules

Confirmed by amino acid analysis and mass spectrometry

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

The first widely used competitive AMPA receptor antagonists were quinoxalinediones (CNQX, DNQX, NBQX), which were highly selective over NMDA receptors but antagonized kainate receptors. CNQX is a potent, competitive AMPA/kainate receptor antagonist. It also acts as an antagonist at the NMDA receptor glycine site.This non-NMDA receptor antagonist inhibits [3H]AMPA binding to quisqualate receptors at submicromolar concentrations. CNQX also selectively blocks the excitatory action of quisqualate and kainate on spinal neurons with little or no effect on that of NMDA.The concentrations that inhibit 50% of [3H]AMPA binding (IC50) for CNQX in dorsal horn neurons is 300 nM1.The association of AMPA receptors with TARP auxiliary subunits converts CNQX from an antagonist to a weak partial agonist. CNQX induces partial domain closure, consistent with the activity of a partial agonist. CNQX blocks both fast AMPA-mediated and slow kainate receptor-mediated mEPSCs2.EC50 values for depression of the monosynaptic ventral root reflex is 1.0 ± 0.3 µM3.Direct binding studies using CNQX as a radioligand show that CNQX binds with high affinity (40 nM) to both high (14 nM) and low (235 nM) affinity AMPA binding sites in rat brain4.

Alomone Labs

AMPA/Kainate receptors

CNQX disodium salt (#C-141) is a highly pure, synthetic, and biologically active compound.

AMPA/Kainate Receptor Antagonist

276.1

Synthetic

C9H2N4O4Na2.

300 nM - 500 µM.

AMPA/kainate receptor antagonist. The concentrations that inhibit 50% of AMPA binding (IC50) for CNQX in dorsal horn neurons and motoneurons are 300 nM-1.3 µM. It was about one-fifth as effective at kainate binding sites1,2. The association of AMPA receptors with TARPs converts CNQX from an antagonist to a weak partial agonist. CNQX binds with high affinity to both high and low affinity AMPA binding sites in rat brain. CNQX is a potent antagonist in electrophysiological responses mediated by non-NMDA receptors. Effects at NMDA receptors are much weaker.

Up to 20 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to 20 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).

It is recommended to prepare stock solutions afresh whenever possible, and avoid long term storage. Otherwise, store in single use aliquots up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

479347-85-8

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

Electrophysiology

6-Cyano-7-nitroquinoxaline-2,3-dione disodium.