Cilnidipine | Alomone Labs C-135 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Cilnidipine

catalog :

C-135

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Cilnidipine blocks L-type CaVchannel currents expressed inXenopusoocytes. - A. Time course of CaV1.2 (co-expressed with ?2?1 and ?1 auxiliary subunits) current elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV delivered every 10 seconds. Application of 10 MCilnidipine(#C-135) inhibits the current amplitude and modifies activation (see panel B. periods of application are indicated by the horizontal bars). B. Representative current traces before and during application of 10 M Cilnidipine as indicated.

image 2 :

Expression of Calnexin in mouse hippocampus - Immunohistochemical staining of mouse hippocampal CA1 region using Anti-CalnexinAntibody (#ACS-009) (1:200). A. Canx staining (green) appears in neurons (horizontal arrow) and astrocytes (vertical arrow). B. GFAP staining of astrocytic fibers (red). C. Merge of panels A and B demonstrates co-localization in some astrocytes. DAPI is used to stain nuclei (blue).

product information

CAT :

C-135

SKU :

C-135_10 mg

Product Name :

Cilnidipine

Group Type :

Non Antibodies

Product Type :

S. Molecules

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Storage before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Cilnidipine (CIL) is a potent slow-acting, anti-sympathetic drug that inhibits N-type (IC50 = 200 nM) and L-type (IC50 = 100 nM) Ca2+ channels and thus alleviates hypertension occurrences. CIL is essentially a dihydropyridine with slow onset and long-term vasodilation effects. It is considered to be a "fourth generation" anti-hypertension drug, effective both in vivo and in vitro1,2-4.In vivo studies have demonstrated CIL to be helpful in mitigating long QT syndrome in a canine model and to reduce ischemic cardiac norepinephrine levels in rabbit model of cardiac infraction. Clinical trials have shown that CIL is highly effective in cases of severe hypertension, that it improves left ventricular function, and is effective in combating hypertension5-8.

Supplier :

Alomone Labs

Target :

L- and N-type Ca2+ channels

Long Description :

Cilnidipine (#C-135) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of L- and N-Type CaV Channels

MW :

492.5

Source :

Synthetic

Molecular formula :

C27H28N2O7.

Effective Concentration :

1-100 µM.

Activity :

Cilnidipine is an L- and N-type Ca2+-channel blocker1.

Reconstitution and Solubility :

10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).

Solubility :

10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98.5%

CAS No :

132203-70-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester.

more info or order :

Alomone Labs product webpage