CP 339818 hydrochloride | Alomone Labs C-115 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

CP 339818 hydrochloride

catalog :

C-115

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Calvo M, Richards N, Schmid A, Barroso A, Zhu L, Ivulic D, et al. Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. elife. 2016;5:e12661 pubmed publisher

image

image 1 :

Alomone LabsCP 339818 hydrochlorideinhibits KV1.3 channels heterologously expressed inXenopusoocytes. - A. Time course of reversible current inhibition of KV1.3 current amplitude by 200 ?MCP 339818 hydrochloride(#C-115). Ramp stimulation; 100 ms from holding potential -100 mV to +20 mV delivered every 10 seconds. B. Superimposed current traces of control and inhibited current as indicated (taken from the experiment in A).

image 2 :

Peptide (C)RSGKYLATEWNTVSK corresponding to amino acid residues 36-50 of rat LPA1 receptor (AccessionP61794). Extracellular N-terminus.

product information

CAT :

C-115

SKU :

C-115_10 mg

Product Name :

CP 339818 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

CP 339818 hydrochloride is a potent KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel. It appears to recognize only the inactivated conformation of KV1.3. CP 339818 hydrochloride inhibits KV1.3 expressed in the brain and in T lymphocyte cells with an IC50 value of ~200 nM. In addition to its effect on KV1.3, CP 339818 inhibits the Shaker-related A-type K+ channel, KV1.4, expressed in brain cells with an IC50 of ~300 nM. CP 339818 is a significantly less potent blocker at KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. CP 339818 is valuable for immune system studies, where the absence of KV1.4 makes it functionally selective for KV1.3, and it has shown suppression of T cell activation. CP 339818 hydrochloride is also valuable for the study of KV1.4 function1.

Supplier :

Alomone Labs

Target :

KV1.3, KV1.4 K+ channels

Long Description :

CP 339818 hydrochloride (#C-115) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of KV1.3 and KV1.4 K+ Channels

MW :

340.9

Source :

Synthetic

Molecular formula :

C21H25ClN2.

Effective Concentration :

1-200 µM.

Activity :

CP 339818 hydrochloride is a KV1.3 and KV1.4 channel blocker1.

Reconstitution and Solubility :

20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Solubility :

20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

185855-91-8

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride.

more info or order :

Alomone Labs product webpage