chemical

Talipexole dihydrochloride

B-140

B-140_10 mg

Talipexole dihydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Talipexole is an azepine derivative, and acts as an agonist of D2 dopamine pre- and postsynaptic receptors, as well as an α2-adrenoceptor agonist and 5-HT3 receptor antagonist1.The purpose of Talipexole is to increase dopamine activity in the central nervous system. It inhibits electrically evoked release of dopamine through activation of D2 synaptic autoreceptors located on dopaminergic terminals. It also causes release of acetylcholine and noradrenalin2,3.Talipexole has been established in a number of clinical trials as an anti-Parkinsonian agent. These trials showed significant improvement in motor activity and in other parkinsonian symptoms including akinesia, rigidity, tremor and gait disturbances. There are several side effects caused by this drug such as drowsiness, dizziness, hallucinations, gastrointestinal discomfort, nausea and loss of appetite3.In addition, talipexole is also expected to be beneficial for the treatment of periodic leg movement disorder and restless leg syndrome4.

Alomone Labs

5-HT3, D2 dopamine, α2-adrenoceptor receptors

Talipexole dihydrochloride (#B-140) is a highly pure, synthetic, and biologically active compound.

An Antagonist of 5-HT3 Channel, an Agonist of D2 Dopamine Receptor and α2-Adrenoceptor

282.23

B-HT 920

Synthetic

C10H15N3S•2HCl.

0.3-300 nM.

B-HT 920 is a blocker of 5-HT3 channels1. It is also an agonist of D2 dopamine receptors and α2-adrenoceptors.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

36085-73-1

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride.