Anti-Slitrk2 (extracellular) Antibody | Alomone Labs ASR-082 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-Slitrk2 (extracellular) Antibody

catalog :

ASR-082

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Jagannath A, Varga N, Dallmann R, Rando G, Gosselin P, Ebrahimjee F, et al. Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice. Nat Commun. 2021;12:2113 pubmed publisher

image

image 1 :

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: - 1,2. Anti-Slitrk2 (extracellular) Antibody (#ASR-082), (1:200).3,4. Anti-Slitrk2 (extracellular) Antibody, preincubated with Slitrk2 (extracellular) Blocking Peptide (#BLP-SR082).

image 2 :

Expression of Slitrk2 in rat striatum - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Slitrk2 (extracellular) Antibody (#ASR-082), (1:200), followed by goat anti-rabbit-AlexaFluor-488. Slitrk2 immunoreactivity (green) appears in striosomal patches (S). Cell nuclei are stained with DAPI (blue).

product information

CAT :

ASR-082

SKU :

ASR-082-CF_0.2 ml

Product Name :

Anti-Slitrk2 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q810C0

Applications :

IHC WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-SR082

Homology :

Rat, human - identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)KASRPPKMRNRPTPR, corresponding to amino acid residues 301-315 of mouse Slitrk2

Product Page - Scientific background :

Slitrk2 (SLIT and NTRK-like family member 2) is a neuronal transmembrane protein widely expressed in the nervous system and found to affect neurite outgrowth1,2. Slitrk2 structure contains tandem leucine-rich repeat (LRR) domains and a single transmembrane domain2.In mammals, the Slitrk family consists of at least six members: Slitrk1- Slitrk6. All Slitrk members apart from Slitrk3 can induce both excitatory and inhibitory synapses1.The Slitrk family is responsible for controlling excitatory and inhibitory synapse formation by forming trans-synaptic adhesions with LAR receptor protein tyrosine phosphatases (PTPs)1,2.Studies show that mutations in SLITRK gene family are linked to several neuropsychiatric disorders including schizophrenia, autism spectrum disorders, Tourette syndrome, and obsessive-compulsive disorder.A single amino acid substitution in Slitrk2 (V89M) impairs synapse formation activity in cultured neurons, but does not affect surface transport, expression, or synapse inducing activity1,2.

Applications may also work in :

IHC WB

Supplier :

Alomone Labs

Target :

SLIT and NTRK-like family member 2, SLITL1

Short Description :

A Rabbit Polyclonal Antibody to Slitrk2

Long Description :

Anti-Slitrk2 (extracellular) Antibody (#ASR-082) is a highly selective antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope, and can potentially be used for detecting the protein in living cells. It has been designed to recognize Slitrk2 from mouse, human, and rat samples.

Negative Control :

BLP-SR082

Positive Control :

Synonyms :

SLIT and NTRK-like family member 2, SLITL1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

SLITRK2

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:200

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage