antibody

Anti-Slitrk1 (extracellular) Antibody

ASR-081

polyclonal

domestic rabbit

nonconjugated

NA

human, mouse, rat

western blot, immunohistochemistry

ASR-081-CF_0.2 ml

Anti-Slitrk1 (extracellular) Antibody

Antibodies

Antibodies

Polyclonal

Q810C1

IHC WB

Human Rat Mouse

Rabbit

BLP-SR081

Human - identical; rat - 14/15 amino acid residues identical

PBS pH7.4

Rabbit IgG

Confirmed by amino acid analysis and mass spectrometry

0.2 ml double distilled water (DDW).

1 mg/ml

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

No Preservative

Extracellular, N-terminus

Unconjugated

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Mouse

(C)RDNKIHSIRKSHFVD, corresponding to amino acid residues 383-397 of mouse Slitrk1

Neurites are key morphological features of neurons, and are classified into axons and dendrites. Leucine-rich repeat (LRR) domains are often found in neurite development-controlling proteins. Slitrk proteins are leucine-rich repeat containing transmembrane proteins, parts of which are similar to Slit and neurotrophin receptor.All six members of the Slitrk family, including Slitrk1, contain putative hydrophobic signal sequences and membrane-spanning regions. Slitrk1 is strongly expressed in the subventricular zone of the cerebral cortex, the pyramidal cell layer of the hippocampus and in the thalamus and hypothalamus1.Slitrk1, can regulate synapse formation between hippocampal neurons. Slitrk1 is enriched in postsynaptic fractions and is localized to excitatory synapses. Overexpression of Slitrk1 in hippocampal neurons increases the number of synaptic contacts on these neurons. Furthermore, decreased expression of Slitrk1 in hippocampal neurons leads to a reduction in the number of excitatory, but not inhibitory, synapses formed in hippocampal neuron cultures. In addition, different leucine rich repeat domains of the extracellular region of Slitrk1 are necessary to mediate interactions with Slitrk binding partners of the LAR receptor protein tyrosine phosphatase family, and to promote dimerization of Slitrk1. In addition, Slitrk1 binds with PSD-95 through its intracellular tail. Thus, through PSD-95, Slitrk1 regulates signaling of NMDA and AMPA receptors2.

IHC WB

Alomone Labs

SLIT and NTRK-like family member 1, Leucine-rich repeat-containing protein 12, LRRC12

A Rabbit Polyclonal Antibody to Slitrk1

Anti-Slitrk1 (extracellular) Antibody (#ASR-081) is a highly selective antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope, and can potentially be used for detecting the protein in living cells. It has been designed to recognize Slitrk1 from mouse, human, and rat samples.

BLP-SR081

NA

SLIT and NTRK-like family member 1, Leucine-rich repeat-containing protein 12, LRRC12

1-2 Business Days

Israel/IL

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

SLITRK1

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Contact Alomone Labs for technical support and product customization

H- Human, M- Mouse, R- Rat

No

Affinity purified on immobilized antigen.

41116161

yes

NA

Western blot analysis

1 µg peptide per 1 µg antibody

1:200-1:300

1:200