antibody

Guinea pig Anti-SCN1A (NaV1.1) Antibody

ASC-001-GP

polyclonal

guinea-pigs

nonconjugated

NA

human, mouse, rat

ASC-001-GP-CF_0.2 ml

Guinea pig Anti-SCN1A (NaV1.1) Antibody

Antibodies

Antibodies

Polyclonal

P04774

WB

Human Rat Mouse

Guinea Pig

BLP-SC001

Mouse, human - identical

PBS pH7.4

Guinea pig total IgG

Confirmed by amino acid analysis and mass spectrometry

0.2 ml double distilled water (DDW).

1 mg/ml

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

No Preservative

Intracellular loop between domains I and II

Unconjugated

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Rat

(C)TASEHSREPSAAGRLSD, corresponding to amino acid residues 465-481 of rat NaV1.1

Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow the flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.94-5. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9)2-3.Mammalian sodium channels are heterotrimers composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit6,7.NaV1.1, also referred to as SCN1A, is a tetrodotoxin-sensitive channel and is broadly expressed in neurons7.Mutations in NaV1.1 are associated with at least two forms of epilepsy. Gain-of-function missense mutations are a primary cause of generalized epilepsy with febrile seizures plus (GEFS+). Loss-of-function mutations cause severe myoclonic epilepsy of infancy (SMEI)8,9.

WB

Alomone Labs

Brain type I sodium channel, BI, Sodium channel protein type 1 subunit α

A Guinea Pig Polyclonal Antibody to SCN1A (NaV1.1) Channel

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the rat NaV1.1 channel. Guinea pig Anti-SCN1A (NaV1.1) Antibody (#ASC-001-GP, formerly AGP-043) raised in guinea pig can be used in western blot analysis. It has been designed to recognize NaV1.1 from rat, human and mouse samples. The antigen used to immunize guinea pigs is the same as Anti-SCN1A (NaV1.1) Antibody (#ASC-001) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.

BLP-SC001

NA

Brain type I sodium channel, BI, Sodium channel protein type 1 subunit α

1-2 Business Days

Israel/IL

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

SCN1A

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Contact Alomone Labs for technical support and product customization

H- Human, M- Mouse, R- Rat

No

Affinity purified on immobilized antigen.

41116161

NA

Western blot analysis

1 µg peptide per 1 µg antibody

Contact Alomone for information

1:200