antibody

Anti-β1-Syntrophin (SNTB1) Antibody

APZ-022

polyclonal

domestic rabbit

nonconjugated

NA

human, mouse, rat

APZ-022-CF_0.2 ml

Anti-β1-Syntrophin (SNTB1) Antibody

Antibodies

Antibodies

Polyclonal

Q99L88

WB

Human Rat Mouse

Rabbit

BLP-PZ022

Rat, human - identical

PBS pH7.4

Rabbit IgG

Confirmed by amino acid analysis and mass spectrometry

0.2 ml double distilled water (DDW).

1 mg/ml

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

No Preservative

Intracellular, PH1 domain

Unconjugated

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Mouse

(C)EQVPESISNQKRGVK, corresponding to amino acid residues 99 -113 of mouse β1-syntrophin

Syntrophins are a family of five membrane associated adaptor proteins with a molecular weight of 58-60 kDa. Adaptor proteins play a crucial role in coordinating signaling events and may act as rescuers in situations where a subversion from normal signaling exists. Syntrophins are characterized by the presence of a PDZ (postsynaptic density protein-95/disc large/zona occludens-1) split PH (pleckstrin homology) domain and a SU (syntrophin unique) domain within their structure.β-1 Syntrophin is a 538 amino acid long protein while β-2 is 540 amino acid in length. Both forms are ubiquitously expressed in mammalian tissues however β-1 is the predominant form. β-1 Syntrophin is the basic form of the protein while α-1 is acidic. Like all forms of syntrophin, β-1 syntrophin may exist as a monomer or dimer within the cell. Almost all isoforms of syntrophin bind to each other.Syntrophin is required for the proper localization expression and function of NaV1.4 and NaV1.5 Na+ channels. Both channels take part of a multi-protein complex in which dystrophin and syntrophin proteins play an important role in determining their expression levels. NaV1.4 and NaV1.5 C-termini consist of the PDZ domain-binding motif formed by the last three residues. The C-terminus of NaV1.5 thus binds with the dystrophin of DGC and this interaction is mediated by and β-syntrophin (and α-syntrophin) proteins1.Syntrophin binds directly to dystrophin at the vicinity of dystrophin's GPC binding site. Another low affinity binding site is presumed to exist at the COOH-terminal region of dystrophin2.

WB

Alomone Labs

Syntrophin-2, SNT2B1, BSYN2, 59 kDa dystrophin-associated protein A1 basic component 1, DAPA1B, Tax interaction protein 43, TIP-43

A Rabbit Polyclonal Antibody to β1-Syntrophin (SNTB1)

Anti-β1-Syntrophin (SNTB1) Antibody (#APZ-022) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize SNTB1 from human, mouse, and rat samples.

BLP-PZ022

NA

Syntrophin-2, SNT2B1, BSYN2, 59 kDa dystrophin-associated protein A1 basic component 1, DAPA1B, Tax interaction protein 43, TIP-43

1-2 Business Days

Israel/IL

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

SNTB1

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Contact Alomone Labs for technical support and product customization

H- Human, M- Mouse, R- Rat

No

Affinity purified on immobilized antigen.

41116161

NA

Western blot analysis

1 µg peptide per 1 µg antibody

Contact Alomone for information

1:500