| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig s2b
| de Torre Minguela C, Barberà Cremades M, Gómez A, MartÃn Sánchez F, PelegrÃn P. Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process. Sci Rep. 2016;6:22586 pubmed publisher |
- western blot; mouse; loading ...; fig 6i
| Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher |
- immunohistochemistry; mouse; loading ...
| Rhodes G, Segars K, Lee Y, Hutcheon A, Rich C, Trinkaus Randall V. Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium. Anal Cell Pathol (Amst). 2021;2021:4793338 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5a
- western blot; mouse; 1:200; loading ...; fig 5a
| Hou X, Dong H, Sun L, Yang M, Cheng H, Chen Y. Purinergic 2X7 Receptor is Involved in the Podocyte Damage of Obesity-Related Glomerulopathy via Activating Nucleotide-Binding and Oligomerization Domain-Like Receptor Protein 3 Inflammasome. Chin Med J (Engl). 2018;131:2713-2725 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 3a
| Barth K, Blasche R, Neiser A, Bramke S, Frank J, Kasper M. P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung. Histochem Cell Biol. 2016;146:757-768 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; fig 4c
- western blot; human; 1:500; fig 2f
| Giannuzzo A, Saccomano M, Napp J, Ellegaard M, Alves F, Novak I. Targeting of the P2X7 receptor in pancreatic cancer and stellate cells. Int J Cancer. 2016;139:2540-52 pubmed publisher |
- western blot; mouse; fig 2
| Karmakar M, Katsnelson M, Dubyak G, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun. 2016;7:10555 pubmed publisher |
| Hu X, Zhao G, Xu M, Zhou H, Li F, Miao Y, et al. Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma. J Neuroinflammation. 2021;18:303 pubmed publisher |
| Tarek B, Bruggisser J, Cattalani F, Posthaus H. Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Clostridium perfringens Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells. Toxins (Basel). 2021;13: pubmed publisher |
| Li C, Chan T, Pan C, Vejvisithsakul P, Lai J, Chen S, et al. EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma. Cell Oncol (Dordr). 2021;44:1133-1150 pubmed publisher |
| Xiang Z, Jiang X, Ji R, Yuan H. Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury. Purinergic Signal. 2021;17:425-438 pubmed publisher |
| Wang A, Wong V, Lee P, Bui B, Dudczig S, Vessey K, et al. Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout. Sci Rep. 2021;11:4184 pubmed publisher |
| Prades S, Heard G, Gale J, Engel T, Kopp R, Nicke A, et al. Functional P2X7 Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia. J Neurosci. 2021;41:2615-2629 pubmed publisher |
| Ge H, Sun M, Wei X, Zhang M, Tu H, Hao Y, et al. Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression. Purinergic Signal. 2020;16:585-599 pubmed publisher |
| Yang C, Shi S, Su Y, Tong J, Li L. P2X7R promotes angiogenesis and tumour-associated macrophage recruitment by regulating the NF-κB signalling pathway in colorectal cancer cells. J Cell Mol Med. 2020;24:10830-10841 pubmed publisher |
| Pereira J, Barreira A, Gomes C, Ornellas F, Ornellas D, Miranda L, et al. Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats. BMC Nephrol. 2020;21:206 pubmed publisher |
| Rafael A, Cairus A, Tizzoni M, Abudara V, Vitureira N. Glial ATP and Large Pore Channels Modulate Synaptic Strength in Response to Chronic Inactivity. Mol Neurobiol. 2020;57:2856-2869 pubmed publisher |
| Le Q, Kim J, Kim K, Van Vu A, Woo S. Distinct shear-induced Ca2+ signaling in the left and right atrial myocytes: Role of P2 receptor context. J Mol Cell Cardiol. 2020;143:38-50 pubmed publisher |
| Olotu C, Kiefmann M, Ronneburg C, Lehmensiek F, Cuvenhaus A, Meidl V, et al. Analysis of purine receptor expression and functionality in alveolar epithelial cells. Purinergic Signal. 2020;16:213-229 pubmed publisher |
| Montilla A, Zabala A, Matute C, Domercq M. Functional and Metabolic Characterization of Microglia Culture in a Defined Medium. Front Cell Neurosci. 2020;14:22 pubmed publisher |
| Lee J, Kang M, Park S, Perez Flores M, Zhang X, Wang W, et al. The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss. Aging (Albany NY). 2019;11:11541-11564 pubmed publisher |
| Chen X, Li H, Wang K, Liang X, Wang W, Hu X, et al. Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors. Front Physiol. 2019;10:1286 pubmed publisher |
| Ribeiro D, Casarotto P, Staquini L, Pinto E Silva M, Biojone C, Wegener G, et al. Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. Peerj. 2019;7:e7834 pubmed publisher |
| Arkhipov S, Potter D, Geurts A, Pavlov T. Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD. Am J Physiol Renal Physiol. 2019;317:F1649-F1655 pubmed publisher |
| Crabbé M, Van der Perren A, Bollaerts I, Kounelis S, Baekelandt V, Bormans G, et al. Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson's Disease. Front Neurosci. 2019;13:799 pubmed publisher |
| Wesslau K, Stein A, Kasper M, Barth K. P2X7 Receptor Indirectly Regulates the JAM-A Protein Content via Modulation of GSK-3β. Int J Mol Sci. 2019;20: pubmed publisher |
| Martínez Frailes C, di Lauro C, Bianchi C, de Diego García L, Sebastián Serrano A, Bosca L, et al. Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality. Front Cell Neurosci. 2019;13:143 pubmed publisher |
| Arkhipov S, Pavlov T. ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity. Biochem Biophys Res Commun. 2019;513:166-171 pubmed publisher |
| Zumerle S, Calì B, Munari F, Angioni R, Di Virgilio F, Molon B, et al. Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis. Cell Rep. 2019;27:1-10.e4 pubmed publisher |
| Gentile T, Simmons S, Tallarida C, Su S, Rom S, Watson M, et al. Synthetic cathinone MDPV enhances reward function through purinergic P2X7 receptor-dependent pathway and increases P2X7 gene expression in nucleus accumbens. Drug Alcohol Depend. 2019;197:22-27 pubmed publisher |
| Arribas Blázquez M, Olivos Oré L, Barahona M, Sánchez de la Muela M, Solar V, Jiménez E, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019;20: pubmed publisher |
| Dhuna K, Felgate M, Bidula S, Walpole S, Bibic L, Cromer B, et al. Ginsenosides Act As Positive Modulators of P2X4 Receptors. Mol Pharmacol. 2019;95:210-221 pubmed publisher |
| Mahdi A, Jiao T, Tratsiakovich Y, Yang J, Ostenson C, Pernow J, et al. Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up₄A-Mediated Vascular Contraction. Int J Mol Sci. 2018;19: pubmed publisher |
| Ali S, Turner J, Fountain S. Constitutive P2Y2 receptor activity regulates basal lipolysis in human adipocytes. J Cell Sci. 2018;131: pubmed publisher |
| Grygorowicz T, Struzynska L. Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis. Inflammopharmacology. 2019;27:129-137 pubmed publisher |
| Grygorowicz T, Dabrowska Bouta B, Struzynska L. Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries. Purinergic Signal. 2018;14:385-393 pubmed publisher |
| Ali S, Turner J, Fountain S. P2Y2 and P2Y6 receptor activation elicits intracellular calcium responses in human adipose-derived mesenchymal stromal cells. Purinergic Signal. 2018;14:371-384 pubmed publisher |
| Gilbert S, Oliphant C, Hassan S, Peille A, Bronsert P, Falzoni S, et al. ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival. Oncogene. 2019;38:194-208 pubmed publisher |
| Kaczmarek Hájek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, et al. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. elife. 2018;7: pubmed publisher |
| Seref Ferlengez Z, Urban Maldonado M, Sun H, Schaffler M, Suadicani S, Thi M. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019;1442:79-90 pubmed publisher |
| Tozzi M, Larsen A, Lange S, Giannuzzo A, Andersen M, Novak I. The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in ?-cells. Sci Rep. 2018;8:8926 pubmed publisher |
| Giacovazzo G, Apolloni S, Coccurello R. Loss of P2X7 receptor function dampens whole body energy expenditure and fatty acid oxidation. Purinergic Signal. 2018;14:299-305 pubmed publisher |
| Fan J, Zhao R, Parro C, Zhao W, Chou H, Robert J, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. J Lipid Res. 2018;59:830-842 pubmed publisher |
| Colombo F, Bastoni M, Nigro A, Podini P, Finardi A, Casella G, et al. Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway. Front Immunol. 2018;9:204 pubmed publisher |
| Liu C, Deng Z, Du E, Xu C. Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells. Mol Med Rep. 2018;17:5851-5859 pubmed publisher |
| Jin H, Han J, Resing D, Liu H, Yue X, Miller R, et al. Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease. Eur J Pharmacol. 2018;820:8-17 pubmed publisher |
| Sáez Orellana F, Fuentes Fuentes M, Godoy P, Silva Grecchi T, Panes J, Guzman L, et al. P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease. Neuropharmacology. 2018;128:366-378 pubmed publisher |
| Arguin G, Bourzac J, Placet M, Molle C, Paquette M, Beaudoin J, et al. The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci Rep. 2017;7:12917 pubmed publisher |
| de Andrade Mello P, Bian S, Savio L, Zhang H, Zhang J, Junger W, et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017;8:67254-67268 pubmed publisher |
| Asatryan L, Ostrovskaya O, Lieu D, Davies D. Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells. Neuropharmacology. 2018;128:11-21 pubmed publisher |
| Luo W, Feldman D, McCallister R, Brophy C, Cheung Flynn J. P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis. Purinergic Signal. 2017;13:579-590 pubmed publisher |
| Huang C, Chi X, Li R, Hu X, Xu H, Li J, et al. Inhibition of P2X7 Receptor Ameliorates Nuclear Factor-Kappa B Mediated Neuroinflammation Induced by Status Epilepticus in Rat Hippocampus. J Mol Neurosci. 2017;63:173-184 pubmed publisher |
| Nowodworska A, van den Maagdenberg A, Nistri A, Fabbretti E. In situ imaging reveals properties of purinergic signalling in trigeminal sensory ganglia in vitro. Purinergic Signal. 2017;13:511-520 pubmed publisher |
| Zhao H, Pan P, Yang Y, Ge H, Chen W, Qu J, et al. Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats. J Neuroinflammation. 2017;14:163 pubmed publisher |
| Amorim R, Araujo M, Valero J, Lopes Cendes I, Pascoal V, Malva J, et al. Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy. Purinergic Signal. 2017;13:467-478 pubmed publisher |
| Baldini C, Santini E, Rossi C, Donati V, Solini A. The P2X7 receptor-NLRP3 inflammasome complex predicts the development of non-Hodgkin's lymphoma in Sjogren's syndrome: a prospective, observational, single-centre study. J Intern Med. 2017;282:175-186 pubmed publisher |
| Menzies R, Booth J, Mullins J, Bailey M, Tam F, Norman J, et al. Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury. EBioMedicine. 2017;19:73-83 pubmed publisher |
| Sander P, Mostafa H, Soboh A, Schneider J, Pala A, Baron A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8:35124-35137 pubmed publisher |
| Nie J, Huang G, Deng S, Bao Y, Liu Y, Feng Z, et al. The purine receptor P2X7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma. Endocr Relat Cancer. 2017;24:287-296 pubmed publisher |
| Parzych K, Zetterqvist A, Wright W, Kirkby N, Mitchell J, Paul Clark M. Differential role of pannexin-1/ATP/P2X7 axis in IL-1? release by human monocytes. FASEB J. 2017;31:2439-2445 pubmed publisher |
| Guzman Aranguez A, Pérez de Lara M, Pintor J. Hyperosmotic stress induces ATP release and changes in P2X7 receptor levels in human corneal and conjunctival epithelial cells. Purinergic Signal. 2017;13:249-258 pubmed publisher |
| Zheng B, Lai R, Li J, Zuo Z. Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery. Brain Behav Immun. 2017;61:365-374 pubmed publisher |
| Hirayama Y, Koizumi S. Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning. Glia. 2017;65:523-530 pubmed publisher |
| Zhang P, Xu Q, Xue L, Zheng H, Yan J, Xiao Y, et al. Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity. CNS Neurosci Ther. 2017;23:145-154 pubmed publisher |
| Metzger M, Walser S, Aprile Garcia F, Dedic N, Chen A, Holsboer F, et al. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal. 2017;13:153-170 pubmed publisher |
| Fischer W, Franke H, Krügel U, Muller H, Dinkel K, Lord B, et al. Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models. PLoS ONE. 2016;11:e0156468 pubmed publisher |
| Jimenez Pacheco A, Diaz Hernandez M, Arribas Blázquez M, Sanz Rodriguez A, Olivos Ore L, Artalejo A, et al. Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy. J Neurosci. 2016;36:5920-32 pubmed publisher |
| Zhang Q, Matsui H, Horiuchi H, Liang X, Sasaki K. A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation. Biochem Biophys Res Commun. 2016;476:438-444 pubmed publisher |
| Seref Ferlengez Z, Maung S, Schaffler M, Spray D, Suadicani S, Thi M. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS ONE. 2016;11:e0155107 pubmed publisher |
| Grygorowicz T, Wełniak Kamińska M, Strużyńska L. Early P2X7R-related astrogliosis in autoimmune encephalomyelitis. Mol Cell Neurosci. 2016;74:1-9 pubmed publisher |
