Anti-KCNQ1 (extracellular) Antibody | Alomone Labs APC-168 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-KCNQ1 (extracellular) Antibody

catalog :

APC-168

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Serrano Novillo C, Oliveras A, Ferreres J, Condom E, Felipe A. Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors. Int J Mol Sci. 2020;21: pubmed publisher

image

image 1 :

Western blot analysis of rat heart lysate (lanes 1 and 3) and mouse heart lysate (lanes 2 and 4): - 1,2. Anti-KCNQ1 (extracellular) Antibody (#APC-168), (1:200).3,4. Anti-KCNQ1 (extracellular) Antibody, preincubated with KCNQ1 (extracellular) Blocking Peptide (#BLP-PC168).

product information

CAT :

APC-168

SKU :

APC-168-CF_0.2 ml

Product Name :

Anti-KCNQ1 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9Z0N7

Applications :

IC IF IFC LCI WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-PC168

Homology :

Mouse - identical; human - 13/14 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

3rd extracellular loop

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)EKDAVNESGRIEFG, corresponding to amino acid residues 284-297 of rat KCNQ1

Product Page - Scientific background :

KCNQ1 (KV7.1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5). The channel has been intensively studied since it was found that together with MinK (Isk) it underlay the cardiac Iks current that controls the duration of the action potential of the human heart. Indeed mutations on either KV7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder that causes arrhythmias and sudden death. Although KV7.1 expression and function has been mainly investigated in relation with cardiac function the channel is widely distributed in epithelial tissues. There it has been implicated in physiological functions such as: regulation of acid secretion in the stomach and Cl- secretion into the colon.

Applications may also work in :

IC IF IFC LCI WB

Supplier :

Alomone Labs

Target :

KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KvLQT1, KCNA9

Short Description :

A Rabbit Polyclonal Antibody to KCNQ1 (KV7.1) Channel

Long Description :

Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat KCNQ1 (KV7.1). Anti-KCNQ1 (extracellular) Antibody (#APC-168) can be used in western blot and live cell imaging applications. It has been designed to recognize KCNQ1 from rat, human and mouse samples.

Negative Control :

BLP-PC168

Positive Control :

Synonyms :

KV7.1, Voltage-gated potassium channel QKT subfamily member 1, KvLQT1, KCNA9

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

KCNQ1

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Cited Application :

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage