Anti-KV1.8 Antibody | Alomone Labs APC-157 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-KV1.8 Antibody

catalog :

APC-157

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) heart lysates: - 1,2. Anti-KV1.8 Antibody (#APC-157), (1:800).3,4. Anti-KV1.8 Antibody, preincubated with Kv1.8 Blocking Peptide (#BLP-PC157).

image 2 :

Peptide (C)KDPETLLPTNDIHR corresponding to amino acid residues 187-200 of human KV1.8 (AccessionQ16322). Intracellular N-terminus.

product information

CAT :

APC-157

SKU :

APC-157-CF_0.2 ml

Product Name :

Anti-KV1.8 Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q16322

Applications :

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-PC157

Homology :

Rat, mouse - 13/14 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, N-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Human

Sequence :

(C)KDPETLLPTNDIHR, corresponding to amino acid residues 187-200 of human KV1.8

Product Page - Scientific background :

Potassium (K+) channels regulate cell membrane potential and modulate a number of important cellular functions. K+ voltage-gated channel subfamily A member 10 (KCNA10) also known as KV1.8 is a voltage-gated K+ (KV) channel gene related to the Shaker family of K+ channels that includes eight members (KV1.1- KV1.8)1. KV1.8 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment and a pore (P) region. Its most distinguishing feature is the presence of a putative cyclic nucleotide-binding (CNB) domain at the COOH terminus2. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP1. The channel displays an unusual inhibitor profile, because in addition to being blocked by classical K+ channel blockers, it is also sensitive to inhibitors of cyclic nucleotide gated cation channel such as verapamil and pimozide3.KV1.8 is detected in kidney, heart, and aorta by northern blot and postulated to participate in renal K+ metabolism and to regulate vascular tone3. A recent study showed that a null mutation of mouse KCNA10 causes significant vestibular and mild hearing dysfunction4. In addition KCNA10 has been associated with Long QT syndrome (LQTS), an arrhythmogenic disorder characterized by prolongation of the QT interval on electrocardiograms (ECGs)5.

Applications may also work in :

Supplier :

Alomone Labs

Target :

Potassium voltage-gated channel subfamily A member 10, Cyclic GMP gated potassium channel, KCNA10, KCN1

Short Description :

A Rabbit Polyclonal Antibody to KV1.8 Channel

Long Description :

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat KV1.8. Anti-KV1.8 Antibody (#APC-157) can be used in western blot analysis. It has been designed to recognize KV1.8 from rat, mouse and human samples.

Negative Control :

BLP-PC157

Positive Control :

Synonyms :

Potassium voltage-gated channel subfamily A member 10, Cyclic GMP gated potassium channel, KCNA10, KCN1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

KCNA10

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:800

more info or order :

Alomone Labs product webpage