Anti-KV8.1 (KCNV1) Antibody | Alomone Labs APC-139 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-KV8.1 (KCNV1) Antibody

catalog :

APC-139

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat brain membranes (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4): - 1-2. Anti-KV8.1 (KCNV1) Antibody (#APC-139), (1:200). 3-4. Anti-KV8.1 (KCNV1) Antibody, preincubated with KV8.1 (KCNV1) Blocking Peptide (BLP-PC139).

product information

CAT :

APC-139

SKU :

APC-139-CF_0.2 ml

Product Name :

Anti-KV8.1 (KCNV1) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

P97557

Applications :

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-PC139

Homology :

Mouse - identical; Human - 13 out of 14 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, N-terminus.

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)KKDTDDQESQHESE, corresponding to amino acid residues 171 - 184 of rat KCNV1

Product Page - Scientific background :

Voltage-gated K+ channels (KV) are large and diverse ion channel family with more than 40 members found in all kingdoms of life. The activity of KV results in the generation and propagation of membrane potential. A wide range of physiological activities are regulated via KV actions among them, cell signaling, proliferation and migration. KV divided into 12 sub-families, KV1- KV12 based on their amino acid sequence homology1. The electrically silent voltage-gated K+ (KVS) is a subfamily of four KV (KV5, KV6, KV8 and KV9) that do not assembles into a functional homotetrameric channel. KVS is known to generate a functional heterotetrameric complex with KV2 subunits at the plasma membrane1,2.KV8.1 is a member of the KVS family that was first cloned in 1996 and share 40% identity with other KV channels. Based on sequence homology KV8.1 appear to contain six transmembrane segments (S1-S6), and cytoplasmic N and C termini. Heterotetrameric Kv2.1/KV8.1 was found to have activation V1/2 of 10 to 19 mV and inactivation V1/2 of -63 mV. In recent studies Kv8.1 is found to be involved in epilepsy 2.

Applications may also work in :

Supplier :

Alomone Labs

Target :

Potassium Voltage-Gated Channel Subfamily V Member 1

Short Description :

A Rabbit Polyclonal antibody to KV8.1 (KCNV1)

Long Description :

Anti-KV8.1 (KCNV1) Antibody (#APC-139) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot. It has been designed to recognize KV8.1 from rat, mouse and human samples.

Negative Control :

BLP-PC139

Positive Control :

Synonyms :

Potassium Voltage-Gated Channel Subfamily V Member 1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

KCNV1

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200-1:500

more info or order :

Alomone Labs product webpage