Anti-KV12.1 (KCNH8) Antibody | Alomone Labs APC-113 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-KV12.1 (KCNH8) Antibody

catalog :

APC-113

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat cortex lysate: - 1. Anti-KV12.1 (KCNH8) Antibody (#APC-113), (1:200).2. Anti-KV12.1 (KCNH8) Antibody, preincubated with Kv12.1/KCNH8 Blocking Peptide (#BLP-PC113).

image 2 :

Peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat KCNH8(AccessionQ9QWS8). Intracellular N-terminal part.

image 3 :

Expression ofAdenosineA2AReceptor in rat piriform cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sections withAnti-AdenosineA2AReceptor (extracellular) Antibody(#AAR-008) followed by donkey-anti-rabbit-biotin and streptavidin-Cy3. AdenosineA2AReceptor immunoreactivity (red) appears in neurons (vertical arrows) and in glial cells in layers 1-2 (horizontal arrows). Cell nuclei are stained with DAPI (blue).

product information

CAT :

APC-113

SKU :

APC-113-CF_0.2 ml

Product Name :

Anti-KV12.1 (KCNH8) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9QWS8

Applications :

Reactivity :

Mouse

Host :

Rabbit

Blocking Peptide :

BLP-PC113

Homology :

Mouse -14/15 amino acid residues identical; human -13/15 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, N-terminal domain

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

EDKKEDRAKGRSRAG(C), corresponding to amino acid residues 143-157 of rat KCNH8

Product Page - Scientific background :

KV12.1 is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. These are the eag (KV10) with two members, the eag-related channels (erg or KV11) and the eag-like K+ channels (elk or KV12) with three members each.As with all members of the family, KV12.1 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N- and C- termini. The functional channel is a tetramer composed of four subunits. It has been suggested that the KV12 subfamily members can form functional heteromultimers within the subfamily.KV12.1 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as the testis, colon and lung.The physiological function of the KV12.1 channel is yet to be established, although a role in the modulation of overall excitability of neurons has been suggested. Currently, there isn't much pharmacological data concerning the modulation of the KV12.1 channel except for blocking of the channel by Ba2+.

Applications may also work in :

Supplier :

Alomone Labs

Target :

Potassium voltage-gated channel subfamily H member 8, Ether-a-go-go-like potassium channel 3, ELK channel 3, Elk1, hElk1

Short Description :

A Rabbit Polyclonal Antibody to KV12.1 Channel

Long Description :

Alomone Labs is pleased to offer Anti-KV12.1 (KCNH8) Antibody (#APC-113) that is directed against a highly conserved epitope of the rat protein. The antibody will also likely recognize human and mouse samples.

Negative Control :

BLP-PC113

Positive Control :

Synonyms :

Potassium voltage-gated channel subfamily H member 8, Ether-a-go-go-like potassium channel 3, ELK channel 3, Elk1, hElk1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

KCNH8

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Cited Application :

IHC

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage