Anti-KCNH5 (EAG-2) Antibody | Alomone Labs APC-053 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-KCNH5 (EAG-2) Antibody

catalog :

APC-053

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Traub R, Hawkins K, Adams N, Hall S, Simon A, Whittington M. Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm. Commun Biol. 2020;3:230 pubmed publisher

image

image 1 :

Western blot analysis of rat brain membranes: - 1. Anti-KCNH5 (EAG-2) Antibody (#APC-053), (1:200). 2. Anti-KCNH5 (EAG-2) Antibody, preincubated with KCNH5/EAG-2 Blocking Peptide (#BLP-PC053).

image 2 :

Peptide (C)RDNKIHSIRKSHFVD corresponding to amino acid residues 383-397 of mouse Slitrk1 (AccessionQ810C1). Extracellular N-terminus.

product information

CAT :

APC-053

SKU :

APC-053-CF_0.2 ml

Product Name :

Anti-KCNH5 (EAG-2) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9EPI9

Applications :

IF IHC WB

Reactivity :

Human Mouse

Host :

Rabbit

Blocking Peptide :

BLP-PC053

Homology :

Human - 18/19 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, C-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)EDPKGSDSENSVTKNPLRK, corresponding to amino acid residues 842-860 of rat KCNH5

Product Page - Scientific background :

KV10.2 is a member of the Ether-a-go-go family of voltage-activated potassium channels. To date, the family includes eight members: the closely related KV10.1 protein, the KV12 (elk) (elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3). The eag subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. No specific pharmacological blocker has been described.Tissue distribution of KV10.2 expression in rats is restricted to neuronal tissue with greater expression in the cortex and thalamus. In humans, KV10.2 mRNA was detected in heart and skeletal muscle in addition to brain. The physiological role of KV10.2 is currently unknown.

Applications may also work in :

IF IHC WB

Supplier :

Alomone Labs

Target :

KV10.2, Ether-a-go-go potassium channel 2, hEAG2

Short Description :

A Rabbit Polyclonal Antibody to KV10.2 Channel

Long Description :

Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of the rat KV10.2 channel. Anti-KCNH5 (EAG-2) Antibody (#APC-053) can be used for western blot and immunohistochemistry applications. It has been designed to recognize KV10.2 from rat and human samples. The antibody is specific for KV10.2 and will not cross-react with KV10.1.

Negative Control :

BLP-PC053

Positive Control :

Synonyms :

KV10.2, Ether-a-go-go potassium channel 2, hEAG2

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

KCNH5

AB Specifictiy :

The antibody is specific for KV10.2 and will not cross-react with KV10.1.

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

KO-Validated :

yes

Cited Application :

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage