Anti-MAGT1 (extracellular) Antibody | Alomone Labs ANT-197 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-MAGT1 (extracellular) Antibody

catalog :

ANT-197

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

product information

CAT :

ANT-197

SKU :

ANT-197-CF_0.2 ml

Product Name :

Anti-MAGT1 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9H0U3

Applications :

IFC IHC LCI WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NT197

Homology :

Mouse - identical Rat 11 out of 13 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus.

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Human

Sequence :

(C)SAQRKKEMVLSEK, corresponding to amino acid residues 28-40 of human MAGT1

Product Page - Scientific background :

Magnesium Transporter 1 (MAGT1) is a 335 amino acid peptide that is a part of the MAGT group of magnesium transporters. Magnesium (Mg2+) plays an essential cellular role, as a cofactor for ATP, nucleic acids, and numerous enzymes. It has been reported that it serves as a second messenger in intracellular signaling, and hence magnesium levels maintenance has a vast effect on cellular steady state 1. In addition to its Mg2+ transporter activity, MAGT1 was also found to be a subunit of the oligosaccharyltransferase (OST) complex, through which it is responsible for protein glycosylation 2,3.MAGT1 was shown to be related to the development of XMEN (X-linked immunodeficiency with magnesium defect, Epstein Barr Virus infection, and neoplasia) syndrome, for which Mg2+ supplementation has been shown to be beneficial. It is also related to atypical ATRX syndrome, intellectual disability and skin abnormalities.Understanding the molecular basis of the involvement of magnesium and its channels in human pathogenesis can lead to the development of new medications for many diseases.

Applications may also work in :

IFC IHC LCI WB

Supplier :

Alomone Labs

Target :

Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1

Short Description :

A Rabbit Polyclonal antibody to MAGT1 (extracellular) magnesium transporter.

Long Description :

Anti-MAGT1 (extracellular) Antibody (#ANT-197) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize MAGT1 from mouse, rat and human samples.

Negative Control :

BLP-NT197

Positive Control :

Synonyms :

Magnesium Transporter 1, Oligosaccharyl Transferase Subunit MAGT1, Implantation-Associated Protein, SLC58A1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

MAGT1

AB Specifictiy :

The immunizing peptide bears some homology (7 out of 13 amino acid residues) with the related protein TUSC3 (Accession Q13454).

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:300

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage