Anti-LAT3/SLC43A1 (extracellular) Antibody | Alomone Labs ANT-193 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-LAT3/SLC43A1 (extracellular) Antibody

catalog :

ANT-193

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat lung (lanes 1 and 3) and mouse lung (lanes 2 and 4) lysates: - 1, 2. Anti-LAT3/SLC43A1 (extracellular) Antibody (#ANT-193), (1:400). 3, 4. Anti-LAT3 (SLC43A1) (extracellular) Antibody, preincubated with LAT3/SLC43A1 (extracellular) Blocking Peptide (#BLP-NT193).

product information

CAT :

ANT-193

SKU :

ANT-193-CF_0.2 ml

Product Name :

Anti-LAT3/SLC43A1 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q8BSM7

Applications :

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NT193

Homology :

Rat - 13/14 amino acid residues identical; human - 10/14 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

4th extracellular loop

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)GKERETNEQRQKVE, corresponding to amino acid residues 336-349 of mouse LAT3 (SLC43A1)

Product Page - Scientific background :

LAT3, (L-type amino acid transporter 3) is an amino acid transporter that belongs to the system L family of membrane transporters.The system L transporter family consists of various transporter subtypes with different characteristics in substrate selectivity and transport properties. It is characterized by a Na+ independent transport and its inhibition by 2-aminobicyclo heptane-2-carboxylicacid (BCH).System L transporters are a major route to provide cells with branched-chain and aromatic amino acids. Transporters that belong to this family are present in the basolateral membrane of epithelial cells and play important roles in the absorption of amino acids through the epithelial cells of the small intestine and renal proximal tubules. They are essential in the permeation of amino acids through the blood-tissue barriers such as blood brain barrier and placenta barrier1.LAT3 consists of seven transmembrane domains with a relatively long extracellular loop with predicted N-linked glycosylation sites between transmembrane domains 1 and 2 and a long intracellular loop with several putative phosphorylation sites between transmembrane domains 6 and 72.LAT3 was shown to be up-regulated in prostate cancer and responsible for the increased uptake of leucine into the tumor cells. Hence, it is an appealing target for cancer therapy3.

Applications may also work in :

Supplier :

Alomone Labs

Target :

Large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, Solute carrier family 43 member 1

Short Description :

A Rabbit Polyclonal Antibody to LAT3 Transporter

Long Description :

Anti-LAT3/SLC43A1 (extracellular) Antibody (#ANT-193) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize SLC43A1 from human, rat, and mouse samples.

Negative Control :

BLP-NT193

Positive Control :

Synonyms :

Large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, Solute carrier family 43 member 1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

SLC43A1

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200-1:400

more info or order :

Alomone Labs product webpage