Anti-GFR alpha 3 (extracellular) Antibody | Alomone Labs ANT-023 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-GFR alpha 3 (extracellular) Antibody

catalog :

ANT-023

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain lysate: - 1. Anti-GFR alpha 3 (extracellular) Antibody (#ANT-023), (1:200).2. Anti-GFR alpha 3 (extracellular) Antibody, preincubated with GFR α 3 (extracellular) Blocking Peptide (#BLP-NT023).

product information

CAT :

ANT-023

SKU :

ANT-023-CF_0.2 ml

Product Name :

Anti-GFR alpha 3 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

O35118

Applications :

Reactivity :

Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NT023

Homology :

Mouse, rat, human - 13/14 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

CDRLRKAYGEA(S)SG, corresponding to amino acid residues 172-185 of mouse GFRA3

Product Page - Scientific background :

GFRα3 (GDNF Family Receptor α3) belongs to the glial cell line derived neurotrophic factor (GDNF) family of receptors which contains four members GFRα1-4. The GDNF family of ligands (GFLs)- GDNF, Neurturin, Artemin, and Persephin bind to co-receptors GFRα1-4 and activate Ret receptor tyrosine kinase. GDNF-family receptor α is glycosyl-phosphatidylinositol anchored to the cell surface. GFRα3 structure contains three homologous domains (D1, D2 and D3) and a C-terminal extension1-4.GFRα3 is a highly selective receptor for Artemin (Artn). Artemin is a vasculature-derived neurotrophic factor that modulates the development and function of sensory neurons and participates in the pathophysiology of peripheral inflammation and pain hyperalgesia.In adults, GFRα3 is restricted to neurons of the peripheral nervous system. The protein is expressed by a subpopulation of nociceptive sensory neurons which also express the Ret receptor tyrosine kinase, TRPV1, TRPA11,2,3.

Applications may also work in :

Supplier :

Alomone Labs

Target :

GFRA3, GFRα3, GDNF family receptor α3, GDNF receptor alpha 3

Short Description :

A Rabbit Polyclonal Antibody to GDNF Family Receptor α3

Long Description :

Anti-GFR alpha 3 (extracellular) Antibody (#ANT-023) is a highly specific antibody directed against an epitope of mouse GDNF receptor α3. The antibody can be used in western blot analysis. It has been designed to recognize GFR α3 from human, mouse, and rat samples.

Negative Control :

BLP-NT023

Positive Control :

Synonyms :

GFRA3, GFRα3, GDNF family receptor α3, GDNF receptor alpha 3

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

GFRA3

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage