Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody | Alomone Labs ANR-193 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody

catalog :

ANR-193

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain lysate (lanes 1 and 3) and rat brain lysate (lanes 2 and 4): - 1-2. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193), (1:400). 3-4. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody, preincubated with Neuronal Pentraxin Receptor (NPTXR)(extracellular) Blocking Peptide (BLP-NR193).

image 2 :

Expression of Neuronal Pentraxin Receptor in rat hippocampus. - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193), (1:1200), followed by donkey anti-rabbit-biotin and streptavidin-Cy3. A. Staining in the rat hippocampal CA3 region, showed NPTXR immunoreactivity (red) in neuronal profiles (arrows) in the pyramidal layer (P). B. Pre-incubation of the antibody with Neuronal Pentraxin Receptor (NPTXR)(extracellular) Blocking Peptide (BLP-NR193), suppressed staining. Cell nuclei are stained with DAPI (blue).

product information

CAT :

ANR-193

SKU :

ANR-193-CF_0.2 ml

Product Name :

Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q99J85

Applications :

IFC IHC LCI WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NR193

Homology :

Rat - identical; human - 14 out of 15 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, C-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR

Product Page - Scientific background :

Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer's disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.

Applications may also work in :

IFC IHC LCI WB

Supplier :

Alomone Labs

Target :

NPR, NPTXR

Short Description :

A Rabbit Polyclonal Antibody to NPTXR (extracellular)

Long Description :

Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193) is a highly specific antibody directed against an extracellular epitope of the mouse NPTXR. The antibody can be used in western blot and immunohistochemistry. It has been designed to recognize NPTXR from mouse, rat and human samples.

Negative Control :

BLP-NR193

Positive Control :

Synonyms :

NPR, NPTXR

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

NPTXR

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:1200

Application Dilutions: Western blot wb :

1:400

more info or order :

Alomone Labs product webpage