Anti-Neuronal Pentraxin 1 (NPTX1) Antibody | Alomone Labs ANR-191 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-Neuronal Pentraxin 1 (NPTX1) Antibody

catalog :

ANR-191

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain membranes (lanes 1 and 3) and rat brain membranes (lanes 2 and 4): - 1-2. Anti-Neuronal Pentraxin 1 (NPTX1) Antibody (#ANR-191), (1:400). 3-4. Anti-Neuronal Pentraxin 1 (NPTX1) Antibody, preincubated with Neuronal Pentraxin 1 (NPTX1) Blocking Peptide (BLP-NR191).

image 2 :

Expression of Neuronal Pentraxin 1 in rat striatum. - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Neuronal Pentraxin 1 (NPTX1) Antibody (#ANR-191), (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. NPTX1 immunoreactivity (green) appears in neuron profiles (arrows). B. Pre-incubation of the antibody with Neuronal Pentraxin 1 (NPTX1) Blocking Peptide (BLP-NR191), suppressed staining. Cell nuclei are stained with DAPI (blue). CC = corpus callosum, ST = striatum.

product information

CAT :

ANR-191

SKU :

ANR-191-CF_0.2 ml

Product Name :

Anti-Neuronal Pentraxin 1 (NPTX1) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q62443

Applications :

IHC WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NR191

Homology :

Rat - identical; Human - 13 out of 15 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Secreted

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)ERAKIESALTSLHQR, corresponding to amino acid residues 197 - 211 of mouse NPTX1

Product Page - Scientific background :

Neuronal Pentraxin 1 (NP1 or NPTX1) is a 47-50 kDa secreted glycoprotein that is expressed in the central nervous system and involved in excitatory synaptic remodeling1. The pentraxin superfamily members are made from monomers arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain with a shorter inner conserved sequence called the pentraxin signature 2.NP1 is preferentially expressed in the brain and is involved in glutamate receptor internalization. It is secreted pre-synaptically and implicated in excitatory synaptic and mitochondrial deficits. In addition, NP1 may represent a potential synapse-derived plasma biomarker that is able to identify alterations in excitatory synapses and early-onset Alzheimer's disease3.

Applications may also work in :

IHC WB

Supplier :

Alomone Labs

Target :

Neuronal Pentraxin-1, NP1

Short Description :

A Rabbit Polyclonal antibody to Neuronal Pentraxin 1 (NPTX1)

Long Description :

Anti-Neuronal Pentraxin 1 (NPTX1) Antibody (#ANR-191) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX1 from rat, mouse and human samples.

Negative Control :

BLP-NR191

Positive Control :

Synonyms :

Neuronal Pentraxin-1, NP1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

NPTX1

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:300

Application Dilutions: Western blot wb :

1:400

more info or order :

Alomone Labs product webpage