Anti-LRRTM1 (extracellular) Antibody | Alomone Labs ANR-141 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-LRRTM1 (extracellular) Antibody

catalog :

ANR-141

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain (lanes 1 and 3) and rat hippocampus (lanes 2 and 4) lysates: - 1,2. Anti-LRRTM1 (extracellular) Antibody (#ANR-141), (1:400).3,4. Anti-LRRTM1 (extracellular) Antibody, preincubated with LRRTM1 (extracellular) Blocking Peptide (#BLP-NR141).

image 2 :

Expression of LRRTM1 in rat cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-LRRTM1 (extracellular) Antibody (#ANR-141), (1:200), followed by goat-anti-rabbit-AlexaFluor-488. LRRTM1 staining (green) in rat temporal cortex is detected in neuronal profiles (arrows). Cell nuclei are stained with DAPI (blue).

product information

CAT :

ANR-141

SKU :

ANR-141-CF_0.2 ml

Product Name :

Anti-LRRTM1 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q8K377

Applications :

IF IHC WB

Reactivity :

Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-NR141

Homology :

Mouse and rat - 12/13 amino acid residues identical; human - 11/13 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)GRYDANLQ(S)ASPE, corresponding to amino acid residues 334-346 of mouse LRRTM1

Product Page - Scientific background :

Leucine rich repeat transmembrane neuronal 1 (LRRTM1) is a synaptogenic, cell adhesion protein that contributes to the regulation of synapse density and synaptic transmission. The LRRTM family in mammals includes four postsynaptic proteins, which have been shown to interact with presynaptic neurexins and heparan sulphate proteoglycan glypican on the presynaptic side1. In human and mouse genomes, LRRTM1 is encoded by a single exon and is predominantly expressed in the nervous system. LRRTM1 is a single-membrane-spanning transmembrane protein and its structure contains ten N-terminal LRR repeats, a single pass transmembrane domain, and a cytoplasmic C-terminal tail comprising a PDZ-binding motif1.Mutations in human genes encoding the LRRTM proteins are implicated in cognitive disorders. In particular, LRRTM1 is associated to human handedness and schizophrenia1,2. Studies on Lrrtm1 knockout mice shows deficits in behavioral responses to stressful situations and novel objects, spatial memory and social discrimination deficits3. LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of LRRTM1 in retinothalamic convergence in vision4.

Applications may also work in :

IF IHC WB

Supplier :

Alomone Labs

Target :

Leucine-rich repeat transmembrane neuronal protein 1

Short Description :

A Rabbit Polyclonal Antibody to LRRTM1

Long Description :

Anti-LRRTM1 (extracellular) Antibody (#ANR-141) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect the protein in living cells. It has been designed to recognize LRRTM1 from human, rat, and mouse samples.

Negative Control :

BLP-NR141

Positive Control :

Synonyms :

Leucine-rich repeat transmembrane neuronal protein 1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

LRRTM1

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:200

Application Dilutions: Western blot wb :

1:400

more info or order :

Alomone Labs product webpage