product summary
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company name :
Alomone Labs
product type :
antibody
product name :
Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular)-PE Antibody
catalog :
ALM-051-PE
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6C1.
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
image
image 1 :

Multiplex staining of TRPV4 and K Ca 3.1 in human BSM cells
image 2 :

Multiplex staining of K Ca 3.1 and P2Y2 in human ovarian carcinoma
image 3 :

Expression of KCNN4 channel in human cytotrophoblasts
product information
CAT :
ALM-051-PE
SKU :
ALM-051-PE_50 mcl
Product Name :
Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular)-PE Antibody
Group Type :
Antibodies
Product Type :
Antibodies
Clonality :
Monoclonal
Accession :
O15554
Applications :
IC IF IFC IHC LCI WB
Reactivity :
Human Rat Mouse
Host :
Mouse
Blocking Peptide :
NA
Homology :
Recognizes KCNN4 from human, rat, and mouse samples
Formulation :
PBS pH7.4, 1% BSA with 0.05% sodium azide
isotype :
IgM
Peptide confirmation :
NA
Reconstitution :
50 µl double distilled water (DDW).
Antibody Concentration After Reconstitut ... :
1 mg/ml
Storage After Reconstitution :
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Preservative :
1% BSA, 0.05% NaN3
Immunogen Location :
Extracellular loop
Label :
R-Phycoerythrin (R-PE).
Storage Before Reconstitution :
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
immunogen source species :
Human
Sequence :
Synthetic peptide mapping to the 3rd extracellular loop of human KCNN4
Product Page - Scientific background :
KCa3.1 (KCNN4, SK4) is a member of the Ca2+ activated K+ channel family that shares the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is, six transmembrane domains and intracellular N- and C-termini. KCa3.1 is widely expressed in epithelial, endothelial and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel. The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCa3.1 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCa3.1 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.
Applications may also work in :
IC IF IFC IHC LCI WB
Supplier :
Alomone Labs
Target :
IKCa1, IK1, Intermediate conductance Ca2+-activated K+ channel protein 4, Gardos channel
Short Description :
A Mouse Monoclonal Antibody to KCNN4 (KCa3.1, SK4) Channel
Long Description :
Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular) Antibody (#ALM-051) is a highly specific monoclonal antibody directed against an epitope of the human channel. The antibody can be used in western blot, immunocytochemistry, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize KCNN4 from human, rat, and mouse samples. Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular)-PE Antibody (#ALM-051-PE) is directly conjugated to R-Phycoerythrin (R-PE) fluorophore. The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
Negative Control :
NA
Positive Control :
NA
Synonyms :
IKCa1, IK1, Intermediate conductance Ca2+-activated K+ channel protein 4, Gardos channel
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot
Specifictiy :
KCNN4
Form :
Lyophilized powder
Comment :
Contact Alomone Labs for technical support and product customization
Species reactivity key :
H- Human, M- Mouse, R- Rat
Is Toxin :
No
Purity :
Affinity purified on immobilized antigen.
UNSPSC :
41116161
Clone :
6C1.
Standard quality control of each lot :
Western blot analysis (unlabeled antibody), and direct flow cytometry (labeled antibody).
Antigen preadsorption control :
NA
Application Dilutions: Immunohistochemis ... :
Contact Alomone for information
Application Dilutions: Western blot wb :
Contact Alomone for information
more info or order :
company information

Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972 2 531 8002
headquarters: Israel
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