Anti-Taurine Transporter (SLC6A6) Antibody | Alomone Labs AGT-006 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-Taurine Transporter (SLC6A6) Antibody

catalog :

AGT-006

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse brain membranes: - 1. Anti-Taurine Transporter (SLC6A6) Antibody (#AGT-006), (1:200).2. Anti-Taurine Transporter (SLC6A6) Antibody, preincubated with Taurine Transporter/SLC6A6 Blocking Peptide (#BLP-GT006).

image 2 :

Western blot analysis of human HL-60 promyelocytic leukemia cell lysate (lanes 1 and 3) and human HT-29 colon adenocarcinoma cell lysate (lanes 2 and 4): - 12.Anti-Taurine Transporter (SLC6A6) Antibody(#AGT-006) (1:200).34. Anti-Taurine Transporter (SLC6A6) Antibody preincubated with the negative control antigen.

image 3 :

Western blot analysis of mouse brain membranes: - 1.Anti-Taurine Transporter (SLC6A6) Antibody(#AGT-006) (1:200).2. Anti-Taurine Transporter (SLC6A6) Antibody preincubated with the negative control antigen.

product information

CAT :

AGT-006

SKU :

AGT-006-CF_0.2 ml

Product Name :

Anti-Taurine Transporter (SLC6A6) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

P31643

Applications :

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-GT006

Homology :

Mouse, human - identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, C-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)TPREPNRWAVEREG, corresponding to amino acid residues 581-594 of rat TauT

Product Page - Scientific background :

Taurine (2-aminoethane-sulfonice acid) is one of the most abundant amino acids found in the human body. It is involved in cell regulation and modulates the concentration of intracellular free calcium. It also plays a substantial role in many other functions varying from neurotransmission in the central nervous system to promotion of cell differentiation in the brain to cytoprotection against oxidative stress1.Taurine is not used for protein synthesis, and in addition to its uptake in nutrition, it can be synthesized in pancreatic mammalian cells by cysteine dioxygenase and sulfinoalanine decarboxylase enzymes2.Taurine is found mainly in organs such as the brain, retina and muscle tissue.The uptake of taurine is conducted through the taurine transporter (TauT). The energy for passage through the transporter is derived by Na+ and Cl- concentration similar to the uptake of other amino acids3. TauT also transports GABA, albeit with a lower affinity. The transporter has twelve transmembrane domains and intracellular N- and C-termini.TauT expression is regulated by cAMP which was found to increase its regulation in MDCK cells and also by PKC via means of post-translational modification. PKC activation leads to reduced taurine transport4. PKC is believed to phosphorylate the highly conserved serine-322 position in the transporter.Taurine deficiency is linked to cardiomyopathies in the hearts of cats and to a decrease in cardiac muscle sensitivity to calcium5 and better understanding of its transport may improve research of these diseases.

Applications may also work in :

Supplier :

Alomone Labs

Target :

Sodium- and chloride-dependent taurine transporter, TauT

Short Description :

A Rabbit Polyclonal Antibody to Taurine Transporter (SLC6A6)

Long Description :

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat TauT. Anti-Taurine Transporter (SLC6A6) Antibody (#AGT-006) can be used in western blot analysis. It has been designed to recognize TauT from mouse, rat and human samples.

Negative Control :

BLP-GT006

Positive Control :

Synonyms :

Sodium- and chloride-dependent taurine transporter, TauT

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

SLC6A6

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage