Anti-GPR26 Antibody | Alomone Labs AGR-066 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-GPR26 Antibody

catalog :

AGR-066

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat DRG lysate (lanes 1 and 4), rat brain lysate (lanes 2 and 5), and mouse brain lysate (lanes 3 and 6):

image 2 :

Western blot analysis of human SH-SY5Y neuroblastoma cell:

image 3 :

Expression of GPR26 in mouse olfactory bulb:

product information

CAT :

AGR-066

SKU :

AGR-066-CF_0.2 ml

Product Name :

Anti-GPR26 Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9QXI3

Applications :

IHC WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-GR066

Homology :

Mouse, Human - 14/15 identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Intracellular, C-terminus.

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)RRSIHSVGLTGDSHS, corresponding to amino acid residues 315 -329 of rat GPR26

Product Page - Scientific background :

GPR26, also known as G protein-coupled receptor 26, is part of the extensive G protein-coupled receptor (GPCR) superfamily, characterized by seven transmembrane domains¹. These receptors primarily mediate cellular responses to various extracellular signals, such as hormones and neurotransmitters, by coupling with intracellular G proteins, leading to signal transduction cascades1,3. GPR26 exhibits high basal activity, stimulating cyclic AMP (cAMP) production in an agonist-independent manner3. It is predominantly expressed in the central nervous system, particularly in the hypothalamus, amygdala, cortex, and striatum3,5. Cellularly, it localizes to neurons and is involved in central nervous system processes2,4. Functionally, GPR26 modulates energy balance via hypothalamic AMPK signaling and influences mood regulation by phosphorylating CREB in the amygdala2,5. p>Inactivation of GPR26 in animal models demonstrates its role in obesity, anxiety, and depression. In vitro, its loss enhances hypothalamic activity, causing hyperphagia and metabolic dysregulation, while in vivo, it leads to reduced phosphorylated CREB levels, contributing to anxiety and depression-like behaviors2,5. Aberrant GPR26 function is implicated in glioblastomas due to epigenetic silencing, linking it to tumorigenesis1. It is also associated with neurodegenerative diseases, where it participates in intranuclear inclusion formation in neurons and glial cells4. Research on GPR26 benefits areas like neuropsychiatric disorders, metabolic diseases, cancer, and neurodegeneration, where its detection and functional studies may inform therapeutic developments1,3.

Applications may also work in :

IHC WB

Supplier :

Alomone Labs

Target :

G Protein-Coupled Receptor 26

Short Description :

A Rabbit Polyclonal antibody to GPR26

Long Description :

Anti-GPR26 Antibody (#AGR-066) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR26 from rat, mouse and human samples.

Negative Control :

BLP-GR066

Positive Control :

Synonyms :

G Protein-Coupled Receptor 26

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

GPR26

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

more info or order :

Alomone Labs product webpage