Anti-GPR37 (extracellular) Antibody | Alomone Labs AGR-049 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-GPR37 (extracellular) Antibody

catalog :

AGR-049

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: - 1,2. Anti-GPR37 (extracellular) Antibody (#AGR-049), (1:200).3,4. Anti-GPR37 (extracellular) Antibody, preincubated with GPR37 (extracellular) Blocking Peptide (#BLP-GR049).

product information

CAT :

AGR-049

SKU :

AGR-049-CF_0.2 ml

Product Name :

Anti-GPR37 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q9QYC6

Applications :

IFC WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-GR049

Homology :

Mouse, human - identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Rat

Sequence :

(C)RVRLKNPFYPLTQE, corresponding to amino acid residues 234-247 of rat GPR37

Product Page - Scientific background :

GPR37 or parkin-associated endothelin-like receptor, is an orphan G-protein coupled receptor (GPCR) almost exclusively expressed in the central nervous system. High levels of the protein are detected in the cerebellum, corpus callosum, caudate nucleus, putamen, substantia nigra, and hippocampus.GPR37 is a substrate of the E3 ubiquitin ligase parkin and acts as a receptor for prosaposin. The protein affects oligodendrocyte differentiation and myelination during development1,2.Studies show that GPR37 is heavily involved in the pathogenesis of Parkinson's disease. Missense mutations of GPR37 substrate E3 ubiquitin ligase parkin result in the accumulation of GPR37 in the brain of Parkinson's disease patients1,2. In addition, GPR37 levels are up-regulated in the brains of juvenile Parkinson disease patients and down-regulated in the amygdala and hippocampus of major depressive disorder patients3.

Applications may also work in :

IFC WB

Supplier :

Alomone Labs

Target :

G-protein coupled receptor 37, Prosaposin receptor GPR37, Parkin-associated endothelin receptor-like receptor, Endothelin B receptor-like protein 1

Short Description :

A Rabbit Polyclonal Antibody to GPR37

Long Description :

Anti-GPR37 (extracellular) Antibody (#AGR-049) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and live cell flow cytometry applications. It has been designed to recognize GPR37 from human, rat and mouse samples.

Negative Control :

BLP-GR049

Positive Control :

Synonyms :

G-protein coupled receptor 37, Prosaposin receptor GPR37, Parkin-associated endothelin receptor-like receptor, Endothelin B receptor-like protein 1

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

GPR37

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

Contact Alomone for information

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage