antibody

Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody

ACR-001-GP

polyclonal

guinea-pigs

nonconjugated

NA

human, mouse, rat

western blot, immunohistochemistry

ACR-001-GP-CF_0.2 ml

Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody

Antibodies

Antibodies

Polyclonal

P20272

IHC WB

Human Rat Mouse

Guinea Pig

BLP-CR001

Human - identical; mouse - 15/16 amino acid residues identical

PBS pH7.4

Guinea pig total IgG

Confirmed by amino acid analysis and mass spectrometry

0.2 ml double distilled water (DDW).

1 mg/ml

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

No Preservative

Extracellular, N-terminus

Unconjugated

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Rat

NKSLSSFKENEENIQC, corresponding to amino acid residues 84-99 of rat CB1 receptor

Cannabinoids have been used in Eastern medicine for many years as pain relievers.1 Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 receptor) and cannabinoid receptor 2 (CB2 receptor).2 The cannabinoid receptors can be distinguished by their amino acid sequences, signaling mechanisms, and tissue distributions.2 Both receptors belong to the G-protein coupled receptor (GPCR) superfamily. CB1 was shown to modulate several Ca2+ and K+ ion channels.2,3CB1 is primarily expressed in the central nervous system. However, expression of CB1 is also detected in the peripheral terminals, in non-neuronal peripheral tissues such as uterus, testes, spleen, as well as in cells of the immune system.3,4CB1 is implicated in many cellular functions such as neurotransmitter release, pain relief, cancer, and obesity.5,6 Growth inhibition of tumor cells was demonstrated following mixed CB1/CB2 agonist treatment in both prostate and non-melanoma skin cancers.5,6 Through their interaction with CB1, cannabinoid compounds stimulate appetite for sweets and palatable foods in particular, making CB1 an attractive therapeutic target for the treatment of obesity and eating disorders.7

IHC WB

Alomone Labs

CB1, CB-R, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor, CNR1

A Guinea Pig Polyclonal Antibody to Cannabinoid Receptor 1 (extracellular)

Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody (#ACR-001-GP) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CB1R from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Cannabinoid Receptor 1 (extracellular) Antibody (#ACR-001) raised in rabbits. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.

BLP-CR001

NA

CB1, CB-R, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor, CNR1

1-2 Business Days

Israel/IL

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

CNR1

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Contact Alomone Labs for technical support and product customization

H- Human, M- Mouse, R- Rat

No

Affinity purified on immobilized antigen.

41116161

NA

Western blot analysis

1 µg peptide per 1 µg antibody

1:200

1:400