| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; rat; 1:1500; fig 6
| Pizzoni A, López González M, Di Giusto G, Rivarola V, Capurro C, Ford P. AQP2 can modulate the pattern of Ca2+ transients induced by store-operated Ca2+ entry under TRPV4 activation. J Cell Biochem. 2018;119:4120-4133 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1c
| Dong Q, Li J, Wu Q, Zhao N, Qian C, Ding D, et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci Rep. 2017;7:42678 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; fig 5
- immunocytochemistry; mouse; 1:100; fig 3
- western blot; mouse; 1:1000; fig 1
| Li Y, Hu H, Butterworth M, Tian J, Zhu M, O Neil R. Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS ONE. 2016;11:e0155006 pubmed publisher |
| Taylor M, Lowery J, Choi C, Francis M. Restricted Intimal Ca2+ Signaling Associated With Cardiovascular Disease. Front Physiol. 2022;13:848681 pubmed publisher |
| Swain S, Romac J, Vigna S, Liddle R. Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice. JCI Insight. 2022;7: pubmed publisher |
| Rao Y, Gai X, Xiong J, Le Y, Sun Y. Transient Receptor Potential Cation Channel Subfamily V Member 4 Mediates Pyroptosis in Chronic Obstructive Pulmonary Disease. Front Physiol. 2021;12:783891 pubmed publisher |
| Zhang P, Xu J, Zhang H, Liu X. Identification of TRPV4 as a novel target in invasiveness of colorectal cancer. BMC Cancer. 2021;21:1264 pubmed publisher |
| Li Q, Cheng Y, Zhang S, Sun X, Wu J. TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway. J Neuroinflammation. 2021;18:271 pubmed publisher |
| Lakk M, Hoffmann G, Gorusupudi A, Enyong E, Lin A, Bernstein P, et al. Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension. J Lipid Res. 2021;62:100145 pubmed publisher |
| Janczi T, Meier F, Fehrl Y, Kinne R, Böhm B, Burkhardt H. A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts. Cells. 2021;10: pubmed publisher |
| Willard V, Leddy H, Palmer D, Wu C, Liedtke W, Guilak F. Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells. 2021;39:1447-1456 pubmed publisher |
| Patel P, Chen Y, Kasetti R, Maddineni P, Mayhew W, Millar J, et al. Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
| Li S, Gao S, Chen Y, Bao H, Li Z, Yao Q, et al. Platelet-derived microvesicles induce calcium oscillations and promote VSMC migration via TRPV4. Theranostics. 2021;11:2410-2423 pubmed publisher |
| De Logu F, Trevisan G, Marone I, Coppi E, Padilha Dalenogare D, Titiz M, et al. Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. BMC Biol. 2020;18:197 pubmed publisher |
| Arya R, Goswami R, Rahaman S. Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation. J Biol Chem. 2021;296:100129 pubmed publisher |
| Feng X, Takayama Y, Ohno N, Kanda H, Dai Y, Sokabe T, et al. Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury. Commun Biol. 2020;3:716 pubmed publisher |
| Liao J, Wu Q, Qian C, Zhao N, Zhao Z, Lu K, et al. TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats. JCI Insight. 2020;5: pubmed publisher |
| Espadas xc1 lvarez H, Mart xed nez Rend xf3 n J, Larre I, Matamoros Volante A, Romero Garc xed a T, Rosenbaum T, et al. TRPV4 activity regulates nuclear Ca2+ and transcriptional functions of β-catenin in a renal epithelial cell model. J Cell Physiol. 2021;236:3599-3614 pubmed publisher |
| Wang H, Zhang B, Wang X, Mao J, Li W, Sun Y, et al. TRPV4 Overexpression Promotes Metastasis Through Epithelial-Mesenchymal Transition in Gastric Cancer and Correlates with Poor Prognosis. Onco Targets Ther. 2020;13:8383-8394 pubmed publisher |
| Sadowska A, Altinay B, Hitzl W, Ferguson S, Wuertz Kozak K. Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7. Front Pharmacol. 2020;11:952 pubmed publisher |
| Cambria E, Arlt M, Wandel S, Krupkova O, Hitzl W, Passini F, et al. TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cells. 2020;9: pubmed publisher |
| Islam M, Mizusawa M, Sharmin M, Hayashi S, Yonekura S. TRPV4 Increases the Expression of Tight Junction Protein-Encoding Genes via XBP1 in Mammary Epithelial Cells. Animals (Basel). 2020;10: pubmed publisher |
| Naik S, Pattanaik K, Eich J, Sparr V, Hauptmann M, Kalsdorf B, et al. Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection. iScience. 2020;23:101206 pubmed publisher |
| MacKay C, Leo M, Fernández Peña C, Hasan R, Yin W, Mata Daboin A, et al. Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure. elife. 2020;9: pubmed publisher |
| Ahn M, Eom Y, Oh J, Cha S, Park K, Son J, et al. Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts. Cardiol J. 2020;27:162-170 pubmed publisher |
| McFarland S, Weber D, Choi C, Lin M, Taylor M. Ablation of Endothelial TRPV4 Channels Alters the Dynamic Ca2+ Signaling Profile in Mouse Carotid Arteries. Int J Mol Sci. 2020;21: pubmed publisher |
| Kumar H, Lim C, Choi H, Joshi H, Kim K, Kim Y, et al. Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury. J Neurosci. 2020;40:1943-1955 pubmed publisher |
| Han X, Kato H, Sato H, Hirofuji Y, Fukumoto S, Masuda K. Accelerated osteoblastic differentiation in patient-derived dental pulp stem cells carrying a gain-of-function mutation of TRPV4 associated with metatropic dysplasia. Biochem Biophys Res Commun. 2020;523:841-846 pubmed publisher |
| Guarino B, Adapala R, Kanugula A, Lenkey N, Dougherty J, Paruchuri S, et al. Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels. Front Cell Dev Biol. 2019;7:344 pubmed publisher |
| Roberts M, Sui G, Wu R, Rong W, Wildman S, Montgomery B, et al. TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. FASEB J. 2020;34:263-286 pubmed publisher |
| Wang S, Geng Q, Huo L, Ma Y, Gao Y, Zhang W, et al. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Front Mol Neurosci. 2019;12:296 pubmed publisher |
| Du G, Li L, Zhang X, Liu J, Hao J, Zhu J, et al. Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes. Exp Biol Med (Maywood). 2020;245:180-189 pubmed publisher |
| Sharma S, Goswami R, Rahaman S. The TRPV4-TAZ mechanotransduction signaling axis in matrix stiffness- and TGFβ1-induced epithelial-mesenchymal transition. Cell Mol Bioeng. 2019;12:139-152 pubmed publisher |
| Huang J, Zhang H, Tan X, Hu M, Shen B. Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-KCa2.3 signaling complex. Clin Interv Aging. 2019;14:1579-1587 pubmed publisher |
| Yap J, Tai Y, Fröhlich J, Fong C, Yin J, Foo Z, et al. Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism. FASEB J. 2019;33:12853-12872 pubmed publisher |
| Nonaka K, Han X, Kato H, Sato H, Yamaza H, Hirofuji Y, et al. Novel gain-of-function mutation of TRPV4 associated with accelerated chondrogenic differentiation of dental pulp stem cells derived from a patient with metatropic dysplasia. Biochem Biophys Rep. 2019;19:100648 pubmed publisher |
| Richter F, Segond von Banchet G, Schaible H. Transient Receptor Potential vanilloid 4 ion channel in C-fibres is involved in mechanonociception of the normal and inflamed joint. Sci Rep. 2019;9:10928 pubmed publisher |
| Naert R, Lopez Requena A, Voets T, Talavera K, Alpizar Y. Expression and Functional Role of TRPV4 in Bone Marrow-Derived CD11c+ Cells. Int J Mol Sci. 2019;20: pubmed publisher |
| Li M, Zhang C, Zong Y, Feng J, Ma T, Hu M, et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;: pubmed publisher |
| Gupta N, Goswami R, Alharbi M, Biswas D, Rahaman S. TRPV4 is a regulator in P. gingivalis lipopolysaccharide-induced exacerbation of macrophage foam cell formation. Physiol Rep. 2019;7:e14069 pubmed publisher |
| Huang R, Wang F, Yang Y, Ma W, Lin Z, Cheng N, et al. Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells. FEBS Open Bio. 2019;9:206-225 pubmed publisher |
| Morgan J, Stewart W, McKee R, Gleghorn J. The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization. Cell Mol Bioeng. 2018;11:309-320 pubmed publisher |
| Sawatani T, Kaneko Y, Doutsu I, Ogawa A, Ishikawa T. TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells. Am J Physiol Cell Physiol. 2019;316:C434-C443 pubmed publisher |
| Sharma S, Goswami R, Zhang D, Rahaman S. TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition. J Cell Mol Med. 2019;23:761-774 pubmed publisher |
| Li Y, Hu H, O Neil R. Caveolae facilitate TRPV4-mediated Ca2+ signaling and the hierarchical activation of Ca2+-activated K+ channels in K+-secreting renal collecting duct cells. Am J Physiol Renal Physiol. 2018;315:F1626-F1636 pubmed publisher |
| Jiang S, Lin Y, Hsieh C. Electroacupuncture at Hua Tuo Jia Ji Acupoints Reduced Neuropathic Pain and Increased GABAA Receptors in Rat Spinal Cord. Evid Based Complement Alternat Med. 2018;2018:8041820 pubmed publisher |
| Mundt N, Spehr M, Lishko P. TRPV4 is the temperature-sensitive ion channel of human sperm. elife. 2018;7: pubmed publisher |
| Kanugula A, Adapala R, Midha P, Cappelli H, Meszaros J, Paruchuri S, et al. Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4. FASEB J. 2019;33:195-203 pubmed publisher |
| Zhao H, Zhang K, Tang R, Meng H, Zou Y, Wu P, et al. TRPV4 Blockade Preserves the Blood-Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage. Front Mol Neurosci. 2018;11:97 pubmed publisher |
| Mannaa M, Markó L, Balogh A, Vigolo E, N diaye G, Kaßmann M, et al. Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion. Sci Rep. 2018;8:4878 pubmed publisher |
| Tomilin V, Reif G, Zaika O, Wallace D, Pochynyuk O. Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells. FASEB J. 2018;32:4612-4623 pubmed publisher |
| Wen L, Wen Y, Ke G, Sun S, Dong K, Wang L, et al. TRPV4 regulates migration and tube formation of human retinal capillary endothelial cells. BMC Ophthalmol. 2018;18:38 pubmed publisher |
| Suresh K, Servinsky L, Jiang H, Bigham Z, Yun X, Kliment C, et al. Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2018;314:L893-L907 pubmed publisher |
| Yu Z, Wang Y, Qin L, Chen H. Functional Cooperation between KCa3.1 and TRPV4 Channels in Bronchial Smooth Muscle Cell Proliferation Associated with Chronic Asthma. Front Pharmacol. 2017;8:559 pubmed publisher |
| Lu T, Wang X, Chai Q, Sun X, Sieck G, Katusic Z, et al. Role of the endothelial caveolae microdomain in shear stress-mediated coronary vasorelaxation. J Biol Chem. 2017;292:19013-19023 pubmed publisher |
| Goswami R, Merth M, Sharma S, Alharbi M, Aranda Espinoza H, Zhu X, et al. TRPV4 calcium-permeable channel is a novel regulator of oxidized LDL-induced macrophage foam cell formation. Free Radic Biol Med. 2017;110:142-150 pubmed publisher |
| Wu Q, Qian C, Zhao N, Dong Q, Li J, Wang B, et al. Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes. Cell Death Dis. 2017;8:e2828 pubmed publisher |
| Gebremedhin D, Zhang D, Weihrauch D, Uche N, Harder D. Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. PLoS ONE. 2017;12:e0176796 pubmed publisher |
| Billert M, Skrzypski M, Sassek M, Szczepankiewicz D, Wojciechowicz T, Mergler S, et al. TRPV4 regulates insulin mRNA expression and INS-1E cell death via ERK1/2 and NO-dependent mechanisms. Cell Signal. 2017;35:242-249 pubmed publisher |
| Sharma S, Goswami R, Merth M, Cohen J, Lei K, Zhang D, et al. TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation. Am J Physiol Cell Physiol. 2017;312:C562-C572 pubmed publisher |
| Mamenko M, Boukelmoune N, Tomilin V, Zaika O, Jensen V, O Neil R, et al. The renal TRPV4 channel is essential for adaptation to increased dietary potassium. Kidney Int. 2017;91:1398-1409 pubmed publisher |
| Ritter K, Southard Smith E. Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract. Front Neurosci. 2016;10:592 pubmed publisher |
| Netti V, Fernández J, Kalstein M, Pizzoni A, Di Giusto G, Rivarola V, et al. TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation. J Cell Biochem. 2017;118:2302-2313 pubmed publisher |
| Okada Y, Shirai K, Miyajima M, Reinach P, Yamanaka O, Sumioka T, et al. Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas. PLoS ONE. 2016;11:e0167200 pubmed publisher |
| Kim S, Barry D, Liu X, Yin S, Munanairi A, Meng Q, et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Sci Signal. 2016;9:ra71 pubmed publisher |
| O Conor C, Ramalingam S, Zelenski N, Benefield H, Rigo I, Little D, et al. Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. Sci Rep. 2016;6:29053 pubmed publisher |
| Jo A, Lakk M, Frye A, Phuong T, Redmon S, Roberts R, et al. Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels. Proc Natl Acad Sci U S A. 2016;113:3885-90 pubmed publisher |
| Yap F, Weber D, Taylor M, Townsley M, Comer B, Maylie J, et al. Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure. Am J Physiol Heart Circ Physiol. 2016;310:H1151-63 pubmed publisher |
| Scheraga R, Abraham S, Niese K, Southern B, Grove L, Hite R, et al. TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis. J Immunol. 2016;196:428-36 pubmed publisher |
